PMC:7781431 / 33193-34443
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1018 | 714-719 | Gene | denotes | GPR37 | Gene:2861 |
1019 | 841-846 | Gene | denotes | GPR37 | Gene:2861 |
1020 | 1020-1024 | Gene | denotes | FPR2 | Gene:2358 |
1021 | 1025-1028 | Gene | denotes | ALX | Gene:84941 |
1022 | 1174-1177 | Gene | denotes | SAA | Gene:6287 |
1023 | 441-444 | Gene | denotes | C5A | Gene:728 |
1024 | 1225-1228 | Gene | denotes | SAA | Gene:6287 |
1025 | 927-930 | Gene | denotes | SAA | Gene:6287 |
1026 | 0-17 | Species | denotes | Hepatitis C virus | Tax:11103 |
1027 | 288-294 | Species | denotes | humans | Tax:9606 |
1028 | 325-330 | Species | denotes | Lemon | Tax:2708 |
1029 | 538-543 | Species | denotes | human | Tax:9606 |
1030 | 19-22 | Species | denotes | HCV | Tax:11103 |
1031 | 158-161 | Species | denotes | HCV | Tax:11103 |
1032 | 414-417 | Species | denotes | HCV | Tax:11103 |
1033 | 428-431 | Species | denotes | HCV | Tax:11103 |
1034 | 481-484 | Species | denotes | HCV | Tax:11103 |
1035 | 660-663 | Species | denotes | HCV | Tax:11103 |
1036 | 695-698 | Species | denotes | HCV | Tax:11103 |
1037 | 913-916 | Species | denotes | HCV | Tax:11103 |
1038 | 966-969 | Species | denotes | HCV | Tax:11103 |
1039 | 665-674 | Chemical | denotes | Vitamin D | MESH:D014807 |
1040 | 199-206 | Disease | denotes | cancers | MESH:D009369 |
1041 | 215-227 | Disease | denotes | liver cancer | MESH:D006528 |
1042 | 229-253 | Disease | denotes | hepatocellular carcinoma | MESH:D006528 |
1043 | 276-284 | Disease | denotes | lymphoma | MESH:D008223 |
1044 | 999-1011 | Disease | denotes | inflammation | MESH:D007249 |
1045 | 1038-1050 | Disease | denotes | liver damage | MESH:D056486 |
1046 | 1202-1214 | Disease | denotes | liver damage | MESH:D056486 |
1047 | 1236-1249 | Disease | denotes | HCV infection | MESH:D006526 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T37 | 0-9 | Phenotype | denotes | Hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
T38 | 178-187 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
T39 | 215-227 | Phenotype | denotes | liver cancer | http://purl.obolibrary.org/obo/HP_0002896 |
T40 | 229-253 | Phenotype | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/HP_0001402 |
T41 | 276-284 | Phenotype | denotes | lymphoma | http://purl.obolibrary.org/obo/HP_0002665 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T330 | 0-146 | Sentence | denotes | Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus of the family Flaviviridae with a small (55–65 nm size) envelope (Lee et al. |
T331 | 147-153 | Sentence | denotes | 2017). |
T332 | 154-308 | Sentence | denotes | The HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphoma in humans (Ferri et al. |
T333 | 309-337 | Sentence | denotes | 2015; Rusyn and Lemon 2014). |
T334 | 338-418 | Sentence | denotes | To date, there appears to be no report on the effectiveness of SPMs against HCV. |
T335 | 419-566 | Sentence | denotes | However, HCV peptide (C5A), an amphiphilic α-helix peptide of HCV, is an activator of the N-formyl peptide receptor in human phagocytes (Lin et al. |
T336 | 567-573 | Sentence | denotes | 2011). |
T337 | 574-664 | Sentence | denotes | This suggests the possibility of interaction between RvD1 and LXA4, FPR families, and HCV. |
T338 | 665-787 | Sentence | denotes | Vitamin D metabolites inhibit HCV and upregulate GPR37 gene expression, which induces cellular autophagy (Gutierrez et al. |
T339 | 788-794 | Sentence | denotes | 2014). |
T340 | 795-926 | Sentence | denotes | PD1 was recently proposed as a new ligand for GPR37, and some studies suggest a possible relationship between PD1 and HCV (Fig. 4). |
T341 | 927-1077 | Sentence | denotes | SAA also has antiviral effects against HCV, however, it induces chronic inflammation through FPR2/ALX, causing liver damage (Abouelasrar Salama et al. |
T342 | 1078-1084 | Sentence | denotes | 2019). |
T343 | 1085-1250 | Sentence | denotes | Although research has not been conducted yet, RvD1 and LXA4, which inhibit the action of SAA, are likely to suppress liver damage caused by SAA during HCV infection. |