PMC:7781431 / 3078-4400 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"106","span":{"begin":448,"end":485},"obj":"Chemical"},{"id":"107","span":{"begin":487,"end":492},"obj":"Chemical"},{"id":"108","span":{"begin":1161,"end":1167},"obj":"Chemical"},{"id":"109","span":{"begin":1172,"end":1178},"obj":"Chemical"},{"id":"110","span":{"begin":0,"end":12},"obj":"Disease"},{"id":"111","span":{"begin":107,"end":119},"obj":"Disease"},{"id":"112","span":{"begin":206,"end":222},"obj":"Disease"},{"id":"113","span":{"begin":287,"end":299},"obj":"Disease"},{"id":"114","span":{"begin":501,"end":513},"obj":"Disease"},{"id":"115","span":{"begin":728,"end":741},"obj":"Disease"}],"attributes":[{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D005231"},{"id":"A110","pred":"tao:has_database_id","subj":"110","obj":"MESH:D007249"},{"id":"A111","pred":"tao:has_database_id","subj":"111","obj":"MESH:D007249"},{"id":"A112","pred":"tao:has_database_id","subj":"112","obj":"MESH:D001102"},{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"MESH:D007249"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Inflammation is an extremely important, self-limiting immune response; however, uncontrolled or unresolved inflammation has been established as a pathophysiological mechanism for various diseases including viral infections, and a cause for prolonged homeostasis imbalance. Resolution of inflammation occurs in an overlapping stage dominated by the spatial and temporal biosynthesis of pro-resolved mediators (Headland and Norling 2015), SPMs, from essential polyunsaturated fatty acids (PUFAs) during inflammation. The SPMs initiate the process of resolution which include restriction or cessation of neutrophil infiltration, counter-regulation of chemokines and cytokines, induction of the neutrophils apoptosis and subsequent efferocytosis (the process by which apoptotic cells are removed by phagocytic cells) by macrophages (Reville et al. 2006), the conversion of macrophages from classically activated (M1) to alternatively activated cells (M2), return of non-apoptotic cells to the vascular system or lymphatic vessels, and the start of the healing process (Fig. 1) (Headland and Norling 2015). These events facilitate proper return homeostasis balance (Serhan and Savill 2005). For a comprehensive review, including structural explanations of SPMs, see reviews (Park et al. 2020; Chiang and Serhan 2017; Lee 2012)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T20","span":{"begin":0,"end":272},"obj":"Sentence"},{"id":"T21","span":{"begin":273,"end":514},"obj":"Sentence"},{"id":"T22","span":{"begin":515,"end":843},"obj":"Sentence"},{"id":"T23","span":{"begin":844,"end":1101},"obj":"Sentence"},{"id":"T24","span":{"begin":1102,"end":1185},"obj":"Sentence"},{"id":"T25","span":{"begin":1186,"end":1281},"obj":"Sentence"},{"id":"T26","span":{"begin":1282,"end":1322},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Inflammation is an extremely important, self-limiting immune response; however, uncontrolled or unresolved inflammation has been established as a pathophysiological mechanism for various diseases including viral infections, and a cause for prolonged homeostasis imbalance. Resolution of inflammation occurs in an overlapping stage dominated by the spatial and temporal biosynthesis of pro-resolved mediators (Headland and Norling 2015), SPMs, from essential polyunsaturated fatty acids (PUFAs) during inflammation. The SPMs initiate the process of resolution which include restriction or cessation of neutrophil infiltration, counter-regulation of chemokines and cytokines, induction of the neutrophils apoptosis and subsequent efferocytosis (the process by which apoptotic cells are removed by phagocytic cells) by macrophages (Reville et al. 2006), the conversion of macrophages from classically activated (M1) to alternatively activated cells (M2), return of non-apoptotic cells to the vascular system or lymphatic vessels, and the start of the healing process (Fig. 1) (Headland and Norling 2015). These events facilitate proper return homeostasis balance (Serhan and Savill 2005). For a comprehensive review, including structural explanations of SPMs, see reviews (Park et al. 2020; Chiang and Serhan 2017; Lee 2012)."}