PMC:7781431 / 29305-30045 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"In animals with HSV, topical administration of RvE1 reduced the influx of CD4+ T cells (both TH1 cells and TH17 cells) and neutrophils, decreased production of inflammatory cytokines including IFNγ and IL-6, and increased levels of the anti-inflammatory cytokine IL-10 (Fig. 4) (Rajasagi et al. 2011). Overall, RvE1 significantly reduced stromal keratitis. Similar results were demonstrated with PD1 (Fig. 4) (Rajasagi et al. 2013). Besides, AT-RvD1 treatment significantly reduced the degree of corneal angiogenesis and the severity of stromal keratitis lesions, and AT-RvD1 treated mice had fewer Th1 and Th17 cells in the infected cornea, as well as the reduced number of inflammatory cells, including neutrophils (Rajasagi et al. 2017).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"839","span":{"begin":74,"end":77},"obj":"Gene"},{"id":"840","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"841","span":{"begin":202,"end":206},"obj":"Gene"},{"id":"842","span":{"begin":263,"end":268},"obj":"Gene"},{"id":"843","span":{"begin":584,"end":588},"obj":"Species"},{"id":"844","span":{"begin":346,"end":355},"obj":"Disease"},{"id":"845","span":{"begin":496,"end":503},"obj":"Disease"},{"id":"846","span":{"begin":545,"end":562},"obj":"Disease"},{"id":"847","span":{"begin":625,"end":633},"obj":"Disease"}],"attributes":[{"id":"A839","pred":"tao:has_database_id","subj":"839","obj":"Gene:920"},{"id":"A840","pred":"tao:has_database_id","subj":"840","obj":"Gene:3458"},{"id":"A841","pred":"tao:has_database_id","subj":"841","obj":"Gene:3569"},{"id":"A842","pred":"tao:has_database_id","subj":"842","obj":"Gene:3586"},{"id":"A843","pred":"tao:has_database_id","subj":"843","obj":"Tax:10090"},{"id":"A844","pred":"tao:has_database_id","subj":"844","obj":"MESH:D007634"},{"id":"A845","pred":"tao:has_database_id","subj":"845","obj":"MESH:D003316"},{"id":"A846","pred":"tao:has_database_id","subj":"846","obj":"MESH:D007634"},{"id":"A847","pred":"tao:has_database_id","subj":"847","obj":"MESH:D007239"},{"subj":"839","pred":"source","obj":"LitCovid-PubTator"},{"subj":"840","pred":"source","obj":"LitCovid-PubTator"},{"subj":"841","pred":"source","obj":"LitCovid-PubTator"},{"subj":"842","pred":"source","obj":"LitCovid-PubTator"},{"subj":"843","pred":"source","obj":"LitCovid-PubTator"},{"subj":"844","pred":"source","obj":"LitCovid-PubTator"},{"subj":"845","pred":"source","obj":"LitCovid-PubTator"},{"subj":"846","pred":"source","obj":"LitCovid-PubTator"},{"subj":"847","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T23","span":{"begin":346,"end":355},"obj":"Phenotype"},{"id":"T24","span":{"begin":545,"end":554},"obj":"Phenotype"}],"attributes":[{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0000491"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0000491"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T292","span":{"begin":0,"end":294},"obj":"Sentence"},{"id":"T293","span":{"begin":295,"end":301},"obj":"Sentence"},{"id":"T294","span":{"begin":302,"end":356},"obj":"Sentence"},{"id":"T295","span":{"begin":357,"end":425},"obj":"Sentence"},{"id":"T296","span":{"begin":426,"end":432},"obj":"Sentence"},{"id":"T297","span":{"begin":433,"end":733},"obj":"Sentence"},{"id":"T298","span":{"begin":734,"end":740},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T292","pred":"source","obj":"LitCovid-sentences"},{"subj":"T293","pred":"source","obj":"LitCovid-sentences"},{"subj":"T294","pred":"source","obj":"LitCovid-sentences"},{"subj":"T295","pred":"source","obj":"LitCovid-sentences"},{"subj":"T296","pred":"source","obj":"LitCovid-sentences"},{"subj":"T297","pred":"source","obj":"LitCovid-sentences"},{"subj":"T298","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93dd","default":true},{"id":"LitCovid-PD-HP","color":"#93ece1"},{"id":"LitCovid-sentences","color":"#ecc793"}]}]}}