PMC:7781431 / 21941-22448 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"643","span":{"begin":37,"end":41},"obj":"Gene"},{"id":"644","span":{"begin":327,"end":332},"obj":"Gene"},{"id":"645","span":{"begin":441,"end":445},"obj":"Gene"},{"id":"646","span":{"begin":101,"end":105},"obj":"Chemical"},{"id":"647","span":{"begin":414,"end":417},"obj":"Chemical"}],"attributes":[{"id":"A643","pred":"tao:has_database_id","subj":"643","obj":"Gene:1241"},{"id":"A644","pred":"tao:has_database_id","subj":"644","obj":"Gene:3586"},{"id":"A645","pred":"tao:has_database_id","subj":"645","obj":"Gene:1241"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"MESH:D007975"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"RvE2 was identified as an additional BLT1 agonist, and the β-arrestin assay showed that RvE2 blocked LTB4-mediated β-arrestin signalling with similar efficacy to RvE1, indicating direct competition with LTB4 (Oh et al. 2012). Various pro-resolving roles of RvE2 have been proposed, including regulation of PMN infiltration and IL-10 production (Oh et al. 2012). However, while RvE1 promotes NADPH oxidase-mediated ROS production through the BLT1, RvE2 and RvE3 do not exhibit this effect (Unno et al. 2018)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T219","span":{"begin":0,"end":218},"obj":"Sentence"},{"id":"T220","span":{"begin":219,"end":225},"obj":"Sentence"},{"id":"T221","span":{"begin":226,"end":354},"obj":"Sentence"},{"id":"T222","span":{"begin":355,"end":361},"obj":"Sentence"},{"id":"T223","span":{"begin":362,"end":500},"obj":"Sentence"},{"id":"T224","span":{"begin":501,"end":507},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"RvE2 was identified as an additional BLT1 agonist, and the β-arrestin assay showed that RvE2 blocked LTB4-mediated β-arrestin signalling with similar efficacy to RvE1, indicating direct competition with LTB4 (Oh et al. 2012). Various pro-resolving roles of RvE2 have been proposed, including regulation of PMN infiltration and IL-10 production (Oh et al. 2012). However, while RvE1 promotes NADPH oxidase-mediated ROS production through the BLT1, RvE2 and RvE3 do not exhibit this effect (Unno et al. 2018)."}