PMC:7781431 / 20830-21728 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
614	0-4	Gene	denotes	BLT1	Gene:1241
615	235-239	Gene	denotes	BLT1	Gene:1241
616	283-287	Gene	denotes	BLT1	Gene:1241
617	379-383	Gene	denotes	BLT1	Gene:1241
618	686-690	Gene	denotes	BLT1	Gene:1241
619	741-745	Gene	denotes	BLT1	Gene:1241
620	836-841	Gene	denotes	NF-κB	Gene:4790
621	469-474	Species	denotes	human	Tax:9606
622	85-99	Chemical	denotes	leukotriene B4	MESH:D007975
623	119-124	Chemical	denotes	lipid	MESH:D008055
624	395-399	Chemical	denotes	U-75
625	453-455	Chemical	denotes	3H	MESH:D014316
626	634-641	Chemical	denotes	calcium	MESH:D002118
627	857-864	Chemical	denotes	calcium	MESH:D002118
628	754-766	Disease	denotes	inflammation	MESH:D007249
629	658-664	CellLine	denotes	HEK293	CVCL:0045

Id	Subject	Object	Predicate	Lexical cue
T209	0-256	Sentence	denotes	BLT1 has also been shown to be a receptor for RvE1 although its clone, high-affinity leukotriene B4 (LTB4) is a potent lipid inflammatory chemoattractant, inducing T helper cell chemotaxis and early effector T cell recruitment through BLT1 (Yokomizo et al.
T210	257-275	Sentence	denotes	1997; Arita et al.
T211	276-282	Sentence	denotes	2007).
T212	283-501	Sentence	denotes	BLT1 shares 21% sequence identity with chemerin1; while this value is relatively low, selective BLT1 antagonist U-75,302 has been demonstrated to replace the binding of [3H]-RvE1 to the human PMN membrane (Arita et al.
T213	502-508	Sentence	denotes	2007).
T214	509-691	Sentence	denotes	Besides, although RvE1 is 100 times less potent than LTB4, it inhibited adenylate cyclase activity and induced intracellular calcium mobilization in HEK293 cells overexpressing BLT1.
T215	692-891	Sentence	denotes	These data indicate the role of RvE1 in reducing BLT1-induced inflammation by RvE1 acting as a partial agonist that competes with LTB4-mediated NF-κB activation and calcium mobilization (Arita et al.
T216	892-898	Sentence	denotes	2007).