PMC:7781431 / 17108-18405 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"GPR18\nGPR18 was discovered as a receptor for RvD2 through GPCR-β-arrestin-based screening (Chiang et al. 2015), and the receptor was referred to as DRV2/GPR18 (Chiang et al. 2017, 2019a). Besides, several other ligands activate DRV2/GPR18. These include endogenous ligands such as N-arachidonylglycine (NAGly), anandamide, a metabolite of the endocannabinoid anandamide, synthetic ligands such as abnormal-cannabidiol (Abn-CBD), and O-1918, a partial agonist, which can be used as a pharmacological tool to inhibit DRV2/GPR18 signalling (Offertaler et al. 2003; Kohno et al. 2006). GPR18 is abundantly expressed in PMNs, monocytes and macrophages (Wang et al. 2014). In addition to the resolution of inflammation, while GPR18 has low structural similarity to the cannabinoid receptors CB1, CB2, and GPR55, it responds to endogenous and synthetic cannabinoid ligands including n-arachidonoyl ethanolamine (AEA), 2-arachidonoyl glycerol (2-AG), Δ9-tetrahydrocannabinol (Δ9-THC), and, arachidonoylcyclopropylamide (ACPA) (McHugh, 2012). Also interestingly, GPR18 is structurally very similar to EBV-induced receptor 2 (EBI2), whose expression is increased more than 20 times in Epstein-Barr virus (EBV) infected cells, and is a GPCR receptor clustered together in the 13q32 (Rosenkilde et al., 2006).","divisions":[{"label":"title","span":{"begin":0,"end":5}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"493","span":{"begin":6,"end":11},"obj":"Gene"},{"id":"494","span":{"begin":153,"end":158},"obj":"Gene"},{"id":"495","span":{"begin":233,"end":238},"obj":"Gene"},{"id":"496","span":{"begin":520,"end":525},"obj":"Gene"},{"id":"497","span":{"begin":582,"end":587},"obj":"Gene"},{"id":"498","span":{"begin":720,"end":725},"obj":"Gene"},{"id":"499","span":{"begin":785,"end":788},"obj":"Gene"},{"id":"500","span":{"begin":790,"end":793},"obj":"Gene"},{"id":"501","span":{"begin":799,"end":804},"obj":"Gene"},{"id":"502","span":{"begin":1054,"end":1059},"obj":"Gene"},{"id":"503","span":{"begin":1116,"end":1120},"obj":"Gene"},{"id":"504","span":{"begin":281,"end":301},"obj":"Chemical"},{"id":"505","span":{"begin":303,"end":308},"obj":"Chemical"},{"id":"506","span":{"begin":311,"end":321},"obj":"Chemical"},{"id":"507","span":{"begin":359,"end":369},"obj":"Chemical"},{"id":"508","span":{"begin":397,"end":417},"obj":"Chemical"},{"id":"509","span":{"begin":419,"end":426},"obj":"Chemical"},{"id":"510","span":{"begin":876,"end":903},"obj":"Chemical"},{"id":"511","span":{"begin":905,"end":908},"obj":"Chemical"},{"id":"512","span":{"begin":911,"end":934},"obj":"Chemical"},{"id":"513","span":{"begin":936,"end":940},"obj":"Chemical"},{"id":"514","span":{"begin":943,"end":966},"obj":"Chemical"},{"id":"515","span":{"begin":968,"end":974},"obj":"Chemical"},{"id":"516","span":{"begin":982,"end":1010},"obj":"Chemical"},{"id":"517","span":{"begin":1012,"end":1016},"obj":"Chemical"},{"id":"518","span":{"begin":700,"end":712},"obj":"Disease"},{"id":"519","span":{"begin":1175,"end":1208},"obj":"Disease"}],"attributes":[{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"Gene:2841"},{"id":"A494","pred":"tao:has_database_id","subj":"494","obj":"Gene:2841"},{"id":"A495","pred":"tao:has_database_id","subj":"495","obj":"Gene:2841"},{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"Gene:2841"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"Gene:2841"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"Gene:2841"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"Gene:1268"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"Gene:1269"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"Gene:9290"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"Gene:2841"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"Gene:1880"},{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"MESH:C465623"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"MESH:C465623"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"MESH:C078814"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"MESH:C078814"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"MESH:C479832"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"MESH:C479832"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"MESH:C557222"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"MESH:C557222"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"MESH:C094503"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"MESH:C094503"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"MESH:D013759"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"MESH:D013759"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"MESH:D007249"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"MESH:D020031"},{"subj":"493","pred":"source","obj":"LitCovid-PubTator"},{"subj":"494","pred":"source","obj":"LitCovid-PubTator"},{"subj":"495","pred":"source","obj":"LitCovid-PubTator"},{"subj":"496","pred":"source","obj":"LitCovid-PubTator"},{"subj":"497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"502","pred":"source","obj":"LitCovid-PubTator"},{"subj":"503","pred":"source","obj":"LitCovid-PubTator"},{"subj":"504","pred":"source","obj":"LitCovid-PubTator"},{"subj":"505","pred":"source","obj":"LitCovid-PubTator"},{"subj":"506","pred":"source","obj":"LitCovid-PubTator"},{"subj":"507","pred":"source","obj":"LitCovid-PubTator"},{"subj":"508","pred":"source","obj":"LitCovid-PubTator"},{"subj":"509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"516","pred":"source","obj":"LitCovid-PubTat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