PMC:7781431 / 15056-15811 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"In addition to chemerin, RvE1 was identified as a second endogenous agonist through a screening program against the GPCR panel (Arita et al. 2007). ERV1 (chemokine like receptor 1, also known as CMKLR1) is a receptor for RvE1, which has been shown to bind more strongly than chemerin (a peptide ligand) (Arita et al. 2005; Wittamer et al. 2004). ERV1 overexpressing mice showed a large increase in phagocytosis upon decreased neutrophil inhibition and decreased neutrophil infiltration (Herrera et al. 2015). Also, RvE2 is a partial agonist compared to RvE1 in CHO-chemerin1 β-arrestin recruitment (Isobe et al. 2012a). However, since there is no additional information on this ligand, further investigation of potential ligand-receptor pairs is required.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"412","span":{"begin":15,"end":23},"obj":"Gene"},{"id":"413","span":{"begin":148,"end":152},"obj":"Gene"},{"id":"414","span":{"begin":154,"end":179},"obj":"Gene"},{"id":"415","span":{"begin":195,"end":201},"obj":"Gene"},{"id":"416","span":{"begin":275,"end":283},"obj":"Gene"},{"id":"417","span":{"begin":346,"end":350},"obj":"Gene"},{"id":"418","span":{"begin":366,"end":370},"obj":"Species"},{"id":"419","span":{"begin":561,"end":564},"obj":"CellLine"}],"attributes":[{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"Gene:5919"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"Gene:2671"},{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"Gene:1240"},{"id":"A415","pred":"tao:has_database_id","subj":"415","obj":"Gene:1240"},{"id":"A416","pred":"tao:has_database_id","subj":"416","obj":"Gene:5919"},{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"Gene:11692"},{"id":"A418","pred":"tao:has_database_id","subj":"418","obj":"Tax:10090"},{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"CVCL:0213"},{"subj":"412","pred":"source","obj":"LitCovid-PubTator"},{"subj":"413","pred":"source","obj":"LitCovid-PubTator"},{"subj":"414","pred":"source","obj":"LitCovid-PubTator"},{"subj":"415","pred":"source","obj":"LitCovid-PubTator"},{"subj":"416","pred":"source","obj":"LitCovid-PubTator"},{"subj":"417","pred":"source","obj":"LitCovid-PubTator"},{"subj":"418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"419","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T141","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T142","span":{"begin":141,"end":147},"obj":"Sentence"},{"id":"T143","span":{"begin":148,"end":316},"obj":"Sentence"},{"id":"T144","span":{"begin":317,"end":338},"obj":"Sentence"},{"id":"T145","span":{"begin":339,"end":345},"obj":"Sentence"},{"id":"T146","span":{"begin":346,"end":501},"obj":"Sentence"},{"id":"T147","span":{"begin":502,"end":508},"obj":"Sentence"},{"id":"T148","span":{"begin":509,"end":611},"obj":"Sentence"},{"id":"T149","span":{"begin":612,"end":619},"obj":"Sentence"},{"id":"T150","span":{"begin":620,"end":755},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T141","pred":"source","obj":"LitCovid-sentences"},{"subj":"T142","pred":"source","obj":"LitCovid-sentences"},{"subj":"T143","pred":"source","obj":"LitCovid-sentences"},{"subj":"T144","pred":"source","obj":"LitCovid-sentences"},{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"},{"subj":"T148","pred":"source","obj":"LitCovid-sentences"},{"subj":"T149","pred":"source","obj":"LitCovid-sentences"},{"subj":"T150","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#dc93ec","default":true},{"id":"LitCovid-sentences","color":"#93ecc2"}]}]}}