PMC:7781431 / 14459-15811 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"Chemerin receptor 1\nChemerin receptor 1 (chemerin1, ChemR23, or ERV1) is expressed on a wide range of immune cells, including monocytes, macrophages, natural killer cells, bone marrow cells, and dendritic cells. Besides, ERV1 has been identified in adipocytes and endothelial cells (Luangsay et al. 2009). ERV1 was initially classified as an orphan GPCR with homology to the formyl peptide receptor (Gantz et al. 1996) and the anaphylatoxin C3a and C5a receptors (Samson et al. 1998) until recently when it was discovered to be a receptor for the chemotactic protein chemerin (Meder et al. 2003).\nIn addition to chemerin, RvE1 was identified as a second endogenous agonist through a screening program against the GPCR panel (Arita et al. 2007). ERV1 (chemokine like receptor 1, also known as CMKLR1) is a receptor for RvE1, which has been shown to bind more strongly than chemerin (a peptide ligand) (Arita et al. 2005; Wittamer et al. 2004). ERV1 overexpressing mice showed a large increase in phagocytosis upon decreased neutrophil inhibition and decreased neutrophil infiltration (Herrera et al. 2015). Also, RvE2 is a partial agonist compared to RvE1 in CHO-chemerin1 β-arrestin recruitment (Isobe et al. 2012a). However, since there is no additional information on this ligand, further investigation of potential ligand-receptor pairs is 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