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PMC:7781431 / 10295-11306 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
313 199-204 Gene denotes COX-2 Gene:5743
314 366-371 Gene denotes ALOX5 Gene:240
315 20-25 Gene denotes COX-2 Gene:5743
316 3-8 Species denotes human Tax:9606
317 313-318 Species denotes human Tax:9606
318 625-630 Species denotes human Tax:9606
319 708-713 Species denotes human Tax:9606
320 43-50 Chemical denotes aspirin MESH:D001241
321 54-66 Chemical denotes atorvastatin MESH:D000069059
322 79-87 Chemical denotes omega-3s MESH:D015525
323 89-92 Chemical denotes DPA MESH:C026219
324 97-114 Chemical denotes clupanodonic acid MESH:C026219
325 116-122 Chemical denotes DPAn-3
326 151-158 Chemical denotes Aspirin MESH:D001241
327 163-175 Chemical denotes atorvastatin MESH:D000069059
328 228-241 Chemical denotes hydroperoxide MESH:D006861
329 714-722 Disease denotes infected MESH:D007239
330 435-439 CellLine denotes RvT1 CVCL:1045
331 471-475 CellLine denotes RvT2 CVCL:1045
332 506-510 CellLine denotes RvT3 CVCL:1045
333 564-568 CellLine denotes RvT4 CVCL:1045
334 792-796 CellLine denotes RvT1 CVCL:1045
335 798-802 CellLine denotes RvT2 CVCL:1045
336 823-827 CellLine denotes RvT2 CVCL:1045
337 833-837 CellLine denotes RvT4 CVCL:1045

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T87 0-150 Sentence denotes In human platelets, COX-2 pre-treated with aspirin or atorvastatin metabolizes omega-3s, DPA and clupanodonic acid (DPAn-3), to 13S-hydroperoxy forms.
T88 151-257 Sentence denotes Aspirin and atorvastatin change the activity of COX-2 from cyclooxygenase to hydroperoxide-forming enzyme.
T89 258-434 Sentence denotes The intermediates formed are transported to the nearby human neutrophils and perhaps by the activity of the ALOX5 enzyme they are metabolized into four polyhydroxy metabolites:
T90 435-594 Sentence denotes RvT1 (7,13R, 20-trihydroxy-DPAn-3); RvT2 (7, 8,13R-trihydroxy-DPAn-3); RvT3 (7,12,13R-trihydroxy-8Z, 10E, 14E, 16Z, 19Z-DPAn-3); RvT4 (7,13R-dihydroxy-DPAn-3).
T91 595-744 Sentence denotes These four RvTs are formed by human neutrophils and vascular endothelial cells and are also found in rodents and human infected tissues (Dalli et al.
T92 745-758 Sentence denotes 2013a, 2015).
T93 759-895 Sentence denotes Recently, the total synthesis of RvT1, RvT2, and its 13R-epimer RvT2, and RvT4 were successfully achieved (Rodriguez and Spur 2020a, b).
T94 896-1011 Sentence denotes Therefore, it is expected that there will be many physiological and pharmacological research on RvTs in the future.