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PMC:7755033 / 90486-97364 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1706 660-662 Species denotes WS Tax:126910
1707 727-735 Chemical denotes Losartan
1708 737-749 Chemical denotes Procainamide MESH:D011342
1709 751-761 Chemical denotes Cinacalcet MESH:D000069449
1710 763-770 Chemical denotes Arbidol MESH:C086979
1711 772-790 Chemical denotes Hydroxychloroquine MESH:D006886
1712 792-802 Chemical denotes Oberadilol
1713 804-814 Chemical denotes Poziotinib MESH:C557213
1722 887-889 Species denotes WS Tax:126910
1723 954-962 Chemical denotes Losartan
1724 964-976 Chemical denotes Procainamide MESH:D011342
1725 978-988 Chemical denotes Cinacalcet MESH:D000069449
1726 990-997 Chemical denotes Arbidol MESH:C086979
1727 999-1017 Chemical denotes Hydroxychloroquine MESH:D006886
1728 1019-1029 Chemical denotes Oberadilol
1729 1031-1041 Chemical denotes Poziotinib MESH:C557213
1738 1130-1132 Species denotes WS Tax:126910
1739 1198-1206 Chemical denotes Losartan
1740 1208-1220 Chemical denotes Procainamide MESH:D011342
1741 1222-1232 Chemical denotes Cinacalcet MESH:D000069449
1742 1234-1241 Chemical denotes Arbidol MESH:C086979
1743 1243-1261 Chemical denotes Hydroxychloroquine MESH:D006886
1744 1263-1273 Chemical denotes Oberadilol
1745 1275-1285 Chemical denotes Poziotinib MESH:C557213
1755 1363-1365 Species denotes WS Tax:126910
1756 1430-1438 Chemical denotes Losartan
1757 1440-1452 Chemical denotes Procainamide MESH:D011342
1758 1454-1464 Chemical denotes Cinacalcet MESH:D000069449
1759 1466-1473 Chemical denotes Arbidol MESH:C086979
1760 1475-1493 Chemical denotes Hydroxychloroquine MESH:D006886
1761 1495-1505 Chemical denotes Oberadilol
1762 1507-1517 Chemical denotes Poziotinib MESH:C557213
1763 1335-1343 Disease denotes Toxicity MESH:D064420
1779 1598-1610 Chemical denotes Withaferin A
1780 1639-1652 Chemical denotes Withanolide A
1781 1723-1734 Chemical denotes Withanolide MESH:D054358
1782 1765-1776 Chemical denotes Withanolide MESH:D054358
1783 1807-1816 Chemical denotes Withanone MESH:C560597
1784 1845-1861 Chemical denotes Viscosalactone B
1785 1890-1899 Chemical denotes Anaferine
1786 1928-1940 Chemical denotes Withasomnine MESH:C568582
1787 1970-1978 Chemical denotes Losartan
1788 2008-2020 Chemical denotes Procainamide MESH:D011342
1789 2050-2060 Chemical denotes Cinacalcet MESH:D000069449
1790 2090-2097 Chemical denotes Arbidol MESH:C086979
1791 2127-2145 Chemical denotes Hydroxychloroquine MESH:D006886
1792 2175-2185 Chemical denotes Oberadilol
1793 2215-2225 Chemical denotes Poziotinib MESH:C557213
1796 2286-2288 Species denotes WS Tax:126910
1797 2517-2519 Species denotes WS Tax:126910
1806 2647-2649 Species denotes WS Tax:126910
1807 2714-2722 Chemical denotes Losartan
1808 2724-2736 Chemical denotes Procainamide MESH:D011342
1809 2738-2748 Chemical denotes Cinacalcet MESH:D000069449
1810 2750-2757 Chemical denotes Arbidol MESH:C086979
1811 2759-2777 Chemical denotes Hydroxychloroquine MESH:D006886
1812 2779-2789 Chemical denotes Oberadilol
1813 2791-2801 Chemical denotes Poziotinib MESH:C557213
1817 4228-4231 Gene denotes pc3 Gene:3853
1818 4078-4081 Gene denotes pc2 Gene:3854
1819 3937-3940 Gene denotes pc1 Gene:7163
1828 5213-5215 Species denotes WS Tax:126910
1829 5280-5288 Chemical denotes Losartan
1830 5290-5302 Chemical denotes Procainamide MESH:D011342
1831 5304-5314 Chemical denotes Cinacalcet MESH:D000069449
1832 5316-5323 Chemical denotes Arbidol MESH:C086979
1833 5325-5343 Chemical denotes Hydroxychloroquine MESH:D006886
1834 5345-5355 Chemical denotes Oberadilol
1835 5357-5367 Chemical denotes Poziotinib MESH:C557213
1839 5699-5702 Gene denotes pc3 Gene:3853
1840 5646-5649 Gene denotes pc2 Gene:3854
1841 5593-5596 Gene denotes pc1 Gene:7163
1850 5816-5818 Species denotes WS Tax:126910
1851 5883-5891 Chemical denotes Losartan
1852 5893-5905 Chemical denotes Procainamide MESH:D011342
1853 5907-5917 Chemical denotes Cinacalcet MESH:D000069449
1854 5919-5926 Chemical denotes Arbidol MESH:C086979
1855 5928-5946 Chemical denotes Hydroxychloroquine MESH:D006886
1856 5948-5958 Chemical denotes Oberadilol
1857 5960-5970 Chemical denotes Poziotinib MESH:C557213
1861 6608-6611 Gene denotes pc3 Gene:3853
1862 6521-6524 Gene denotes pc2 Gene:3854
1863 6435-6438 Gene denotes pc1 Gene:7163

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T926 0-5 Sentence denotes 3.10.
T927 7-35 Sentence denotes Principle component analysis
T928 36-214 Sentence denotes PCA is one of the most familiar methods of multivariate analysis which attempts to model the total variance of originally formed data set with the unrelated principal components.
T929 215-432 Sentence denotes Absorption rate, TPSA, MW, clog P, NOHNH, NON, number of rotatable bonds and Lipinski’s violations were the various variable properties on which PCA was performed using linear correlation as shown in Figure 6A and 6B.
T930 433-613 Sentence denotes PCA analysis was also performed on leadlikeness (Table 14; Figure 7) as well as for bioactivity score parameters using linear correlation between the variables (Table 13; Figure 8)
T931 614-623 Sentence denotes Figure 6.
T932 625-852 Sentence denotes PCA of physiological properties of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T933 853-862 Sentence denotes Figure 7.
T934 864-1079 Sentence denotes PCA of leadlikeness of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T935 1080-1089 Sentence denotes Figure 8.
T936 1091-1323 Sentence denotes PCA of bioactivity score prediction of WS phytoconstituents versus FDA– approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib). (A) Scatter Plot (B) 3D Point Plot.
T937 1324-1333 Sentence denotes Table 15.
T938 1335-1519 Sentence denotes Toxicity risk assessment of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib).
T939 1520-1522 Sentence denotes S.
T940 1523-1526 Sentence denotes No.
T941 1528-1593 Sentence denotes Ligands Mutagenic Tumorigenic Reproductive effective Irritant
T942 1594-1596 Sentence denotes 1.
T943 1598-1634 Sentence denotes Withaferin A None None Mild None
T944 1635-1637 Sentence denotes 2.
T945 1639-1676 Sentence denotes Withanolide A None Mild Mild Mild
T946 1677-1679 Sentence denotes 3.
T947 1681-1718 Sentence denotes Withanolide B None Mild Mild Mild
T948 1719-1721 Sentence denotes 4.
T949 1723-1760 Sentence denotes Withanolide D None None Mild None
T950 1761-1763 Sentence denotes 5.
T951 1765-1802 Sentence denotes Withanolide E None None Mild None
T952 1803-1805 Sentence denotes 6.
T953 1807-1840 Sentence denotes Withanone None Mild Mild Mild
T954 1841-1843 Sentence denotes 7.
T955 1845-1885 Sentence denotes Viscosalactone B None None None None
T956 1886-1888 Sentence denotes 8.
T957 1890-1923 Sentence denotes Anaferine None None None None
T958 1924-1926 Sentence denotes 9.
T959 1928-1964 Sentence denotes Withasomnine None None None None
T960 1965-1968 Sentence denotes 10.
T961 1970-2002 Sentence denotes Losartan None None None None
T962 2003-2006 Sentence denotes 11.
T963 2008-2044 Sentence denotes Procainamide None None None High
T964 2045-2048 Sentence denotes 12.
T965 2050-2084 Sentence denotes Cinacalcet None High None None
T966 2085-2088 Sentence denotes 13.
T967 2090-2121 Sentence denotes Arbidol None None None None
T968 2122-2125 Sentence denotes 14.
T969 2127-2169 Sentence denotes Hydroxychloroquine High None None None
T970 2170-2173 Sentence denotes 15.
T971 2175-2209 Sentence denotes Oberadilol None High None None
T972 2210-2213 Sentence denotes 16.
T973 2215-2428 Sentence denotes Poziotinib High Mild Mild Mild As is evident from Figures 6–8, all WS phytoconstituents fall close in 3D to the standard reference drugs used in the present study, thereby denoting their ‘drug-like’ character.
T974 2429-2583 Sentence denotes Tables 16, 17 and 18 represent the Bravais–Pearson (linear correlation) coefficients of WS phytoconstituents versus FDA-approved standard reference drugs.
T975 2584-2593 Sentence denotes Table 16.
T976 2595-2834 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for physicochemical properties.
T977 2835-2903 Sentence denotes Properties   1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
T978 2904-3030 Sentence denotes % AB 1   –0.719 –0.867 0.387 –0.807 0.0443 –1 0.274 0.99 –0.0259 0.037 –0.0781 0.0966 –0.0537 0.0186 5.38E–05
T979 3031-3159 Sentence denotes (NOHNH) 2 –0.719   0.582 –0.357 0.399 0.243 0.719 –0.466 –0.779 0.214 0.45 –0.346 0.156 0.032 –0.0146 –1.39E–08
T980 3160-3292 Sentence denotes (NON) 3 –0.867 0.582   0.0762 0.938 –0.0124 0.867 0.11 –0.893 –0.397 –0.147 –0.119 –0.00919 –0.0307 0.0873 2.76E–09
T981 3293-3421 Sentence denotes LV 4 0.387 –0.357 0.0762   0.0607 0.182 –0.387 0.76 0.35 –0.822 –0.0907 –0.427 –0.103 –0.00279 –0.0306 1.09E–08
T982 3422-3548 Sentence denotes MW 5 –0.807 0.399 0.938 0.0607   0.012 0.807 0.278 –0.821 –0.491 –0.203 0.157 0.0848 –0.0985 –0.0469 5.89E–10
T983 3549-3678 Sentence denotes RB 6 0.0443 0.243 –0.0124 0.182 0.012   –0.0443 0.363 0.0185 –0.386 0.905 0.157 –0.0754 –0.0364 0.00653 4.45E–09
T984 3679-3807 Sentence denotes TPSA 7 –1 0.719 0.867 –0.387 0.807 –0.0443   –0.274 –0.99 0.0259 –0.0371 0.0782 –0.0964 0.0537 –0.0186 5.38E–05
T985 3808-3936 Sentence denotes clog Pc 8 0.274 –0.466 0.11 0.76 0.278 0.363 –0.274   0.264 –0.931 –0.0242 0.205 0.112 0.0929 0.00734 –1.71E–08
T986 3937-4077 Sentence denotes pc1 9 0.99 –0.779 –0.893 0.35 –0.821 0.0185 –0.99 0.264   9.62E–09 –8.89E–09 5.33E–09 –1.73E–08 6.60E–09 –5.23E–09 1.16E–08
T987 4078-4227 Sentence denotes pc2 10 –0.0259 0.214 –0.397 –0.822 –0.491 –0.386 0.0259 –0.931 9.62E–09   –5.16E–09 –9.75E–09 –1.46E–08 –1.70E–09 3.02E–10 –8.98E–10
T988 4228-4377 Sentence denotes pc3 11 0.037 0.45 –0.147 –0.0907 –0.203 0.905 –0.0371 –0.0242 –8.89E–09 –5.16E–09   1.02E–08 –8.09E–09 –2.00E–09 –2.34E–08 –1.94E–08
T989 4378-4523 Sentence denotes pc4 12 –0.0781 –0.346 –0.119 –0.427 0.157 0.157 0.0782 0.205 5.33E–09 –9.75E–09 1.02E–08   –7.30E–09 9.18E–09 –6.69E–09 5.02E–09
T990 4524-4674 Sentence denotes pc5 13 0.0966 0.156 –0.00919 –0.103 0.0848 –0.0754 –0.0964 0.112 –1.73E–08 –1.46E–08 –8.09E–09 –7.30E–09   4.55E–09 9.35E–09 2.03E–09
T991 4675-4827 Sentence denotes pc6 14 –0.0537 0.032 –0.0307 –0.00279 –0.0985 –0.0364 0.0537 0.0929 6.60E–09 –1.70E–09 –2.00E–09 9.18E–09 4.55E–09   6.33E–09 –1.14E–08
T992 4828-4982 Sentence denotes pc7 15 0.0186 –0.0146 0.0873 –0.0306 –0.0469 0.00653 –0.0186 0.00734 –5.23E–09 3.02E–10 –2.34E–08 –6.69E–09 9.35E–09 6.33E–09   –1.39E–08
T993 4983-5149 Sentence denotes pc8 16 5.38E–05 –1.39E–08 2.76E–09 1.09E–08 5.89E–10 4.45E–09 5.38E–05 –1.71E–08 1.16E–08 –8.98E–10 –1.94E–08 5.02E–09 2.03E–09 –1.14E–08 –1.39E–08  
T994 5150-5159 Sentence denotes Table 17.
T995 5161-5411 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for drug like properties and leadlikeness.
T996 5412-5443 Sentence denotes Properties   1 2 3 4 5 6
T997 5444-5489 Sentence denotes LL 1   –0.669 0.631 0.858 –0.51 –0.066
T998 5490-5543 Sentence denotes clog Pc 2 –0.669   –0.754 –0.912 –0.173 –0.372
T999 5544-5592 Sentence denotes clogS 3 0.631 –0.754   0.896 0.311 –0.316
T1000 5593-5645 Sentence denotes pc1 4 0.858 –0.912 0.896   –1.95E–09 1.70E–09
T1001 5646-5698 Sentence denotes pc2 5 –0.51 –0.173 0.311 –1.95E–09   8.57E–10
T1002 5699-5752 Sentence denotes pc3 6 –0.066 –0.372 –0.316 1.70E–09 8.57E–10  
T1003 5753-5762 Sentence denotes Table 18.
T1004 5764-6005 Sentence denotes Bravais–Pearson (linear correlation) coefficient of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) for bioactivity score prediction.
T1005 6006-6050 Sentence denotes Properties   1 2 3 4 5 6 7 8 9 10
T1006 6051-6124 Sentence denotes EI 1   0.0219 0.658 0.923 0.689 0.901 0.37 0.114 –0.0254 0.193
T1007 6125-6204 Sentence denotes GPCR 2 0.0219   0.317 –0.0436 0.573 0.354 –0.894 0.229 –0.148 0.0199
T1008 6205-6281 Sentence denotes ICM 3 0.658 0.317   0.543 0.762 0.849 –0.13 –0.501 –0.101 –0.0238
T1009 6282-6358 Sentence denotes NRL 4 0.923 –0.0436 0.543   0.599 0.836 0.456 0.244 –0.106 –0.151
T1010 6359-6434 Sentence denotes PI 5 0.689 0.573 0.762 0.599   0.905 –0.318 0.0426 0.276 –0.0383
T1011 6435-6520 Sentence denotes pc1 6 0.901 0.354 0.849 0.836 0.905   1.08E–09 8.12E–09 –3.79E–09 1.67E–08
T1012 6521-6607 Sentence denotes pc2 7 0.37 –0.894 –0.13 0.456 –0.318 1.08E–09   7.21E–09 1.03E–09 –4.17E–09
T1013 6608-6694 Sentence denotes pc3 8 0.114 0.229 –0.501 0.244 0.0426 8.12E–09 7.21E–09   4.11E–09 3.79E–10
T1014 6695-6785 Sentence denotes pc4 9 –0.0254 –0.148 –0.101 –0.106 0.276 –3.79E–09 1.03E–09 4.11E–09   9.73E–09
T1015 6786-6878 Sentence denotes pc5 10 0.193 0.0199 –0.0238 –0.151 –0.0383 1.67E–08 –4.17E–09 3.79E–10 9.73E–09