| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T896 |
0-148 |
Sentence |
denotes |
Biotransformation refers to a biochemical modification process of xenobiotics inside the living system involving the utilization of special enzymes. |
| T897 |
149-222 |
Sentence |
denotes |
In pharmaceutical industry, this term is equivalent to ‘drug metabolism’. |
| T898 |
223-425 |
Sentence |
denotes |
Drug metabolism influences drug-like properties of prospective drug molecules which may contribute to the production of metabolites with drastically altered pharmacological and toxicological parameters. |
| T899 |
426-617 |
Sentence |
denotes |
The recognition of SOMs containing specific atom(s) in the molecule which are oxidized by CYP isozymes, provides knowledge for the design and optimization of potent candidates in early stage. |
| T900 |
618-727 |
Sentence |
denotes |
Cytochrome P450s are accountable for more than 90% of the pharmaceutical drugs to undergo phase I metabolism. |
| T901 |
728-886 |
Sentence |
denotes |
Therefore, having prior knowledge about the metabolic liabilities of prospective drug candidates could have important ramifications in drug discovery process. |
| T902 |
887-1045 |
Sentence |
denotes |
The primary, secondary and tertiary predicted SOMs for selected WS phytoconstituents versus FDA-approved standard reference drugs have been shown in Figure 4. |
| T903 |
1046-1137 |
Sentence |
denotes |
The figure is a graphical output for a combination of all nine isozymes of cytochrome P450. |
| T904 |
1138-1283 |
Sentence |
denotes |
The results indicated that WS phytoconstituents and standard reference drugs were predicted to possess SOMs likely to undergo phase I metabolism. |
