PMC:7755033 / 84790-85730 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1532","span":{"begin":683,"end":689},"obj":"Species"},{"id":"1533","span":{"begin":595,"end":607},"obj":"Chemical"},{"id":"1542","span":{"begin":756,"end":758},"obj":"Species"},{"id":"1543","span":{"begin":823,"end":831},"obj":"Chemical"},{"id":"1544","span":{"begin":833,"end":845},"obj":"Chemical"},{"id":"1545","span":{"begin":847,"end":857},"obj":"Chemical"},{"id":"1546","span":{"begin":859,"end":866},"obj":"Chemical"},{"id":"1547","span":{"begin":868,"end":886},"obj":"Chemical"},{"id":"1548","span":{"begin":888,"end":898},"obj":"Chemical"},{"id":"1549","span":{"begin":900,"end":910},"obj":"Chemical"}],"attributes":[{"id":"A1532","pred":"tao:has_database_id","subj":"1532","obj":"Tax:9606"},{"id":"A1533","pred":"tao:has_database_id","subj":"1533","obj":"MESH:D054358"},{"id":"A1542","pred":"tao:has_database_id","subj":"1542","obj":"Tax:126910"},{"id":"A1544","pred":"tao:has_database_id","subj":"1544","obj":"MESH:D011342"},{"id":"A1545","pred":"tao:has_database_id","subj":"1545","obj":"MESH:D000069449"},{"id":"A1546","pred":"tao:has_database_id","subj":"1546","obj":"MESH:C086979"},{"id":"A1547","pred":"tao:has_database_id","subj":"1547","obj":"MESH:D006886"},{"id":"A1549","pred":"tao:has_database_id","subj":"1549","obj":"MESH:C557213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"3.7. Ligand-based target prediction analysis\nSimilarity in structures of ligands or distribution of electrostatic potential may result in an identical effect leading to the probability of interaction with similar targets (Wirth \u0026 Sauer, 2011). These predictions also indicate how a drug candidate can be chemically altered in order to maximize its effect on a given target by comparing it to known ligands having similar structure. Thus, this prediction analysis can help harness natural ligands for use as therapeutic adducts. From the pie-chart representation, it is evident that most of the withanolides possessed broad-spectrum of bioactivity against several targets present in humans (Figure 3).\nFigure 3. Ligand–based target prediction analysis of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) using SwissTargetPrediction."}

{"project":"LitCovid-sentences","denotations":[{"id":"T886","span":{"begin":0,"end":4},"obj":"Sentence"},{"id":"T887","span":{"begin":6,"end":45},"obj":"Sentence"},{"id":"T888","span":{"begin":46,"end":244},"obj":"Sentence"},{"id":"T889","span":{"begin":245,"end":432},"obj":"Sentence"},{"id":"T890","span":{"begin":433,"end":528},"obj":"Sentence"},{"id":"T891","span":{"begin":529,"end":701},"obj":"Sentence"},{"id":"T892","span":{"begin":702,"end":711},"obj":"Sentence"},{"id":"T893","span":{"begin":713,"end":940},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"3.7. Ligand-based target prediction analysis\nSimilarity in structures of ligands or distribution of electrostatic potential may result in an identical effect leading to the probability of interaction with similar targets (Wirth \u0026 Sauer, 2011). These predictions also indicate how a drug candidate can be chemically altered in order to maximize its effect on a given target by comparing it to known ligands having similar structure. Thus, this prediction analysis can help harness natural ligands for use as therapeutic adducts. From the pie-chart representation, it is evident that most of the withanolides possessed broad-spectrum of bioactivity against several targets present in humans (Figure 3).\nFigure 3. Ligand–based target prediction analysis of WS phytoconstituents versus FDA–approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib) using SwissTargetPrediction."}