PMC:7755033 / 80877-82344 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":"Table 13. Bioactivity scores and Druglikeness of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib).\nS. No. Ligands Parameters of bioactivity score\nGPCR ligand Ion channel modulator (ICM) Kinase inhibitor (KI) Nuclear receptor ligand (NRL) Protease inhibitor (PI) Enzymeinhibitor (EI)  \n                 \n1. Withaferin A 0.07 0.14 –0.49 0.76 0.15 0.94  \n2. Withanolide A 0.04 0.32 –0.43 0.71 0.15 0.86  \n3. Withanolide B 0.07 0.24 –0.47 0.79 0.15 0.76  \n4. Withanolide D 0.05 0.30 –0.50 0.73 0.16 1.07  \n5. Withanolide E –0.70 0.16 –0.50 0.61 0.06 0.89  \n6. Withanone 0.00 0.27 –0.38 0.71 0.12 0.78  \n7. Viscosalactone B 0.03 0.04 –0.51 0.78 0.19 0.84  \n8. Anaferine –0.08 0.17 –0.60 –0.58 –0.14 0.08  \n9. Withasomnine –0.49 –0.43 0.58 –0.10 –0.58 –0.17  \n10. Losartan 1.06 0.16 0.03 0.01 0.33 0.44  \n11. Procainamide –0.09 0.01 –0.10 –0.70 –0.20 –0.04  \n12. Cinacalcet 0.22 0.15 –0.0.8 0.00 0.17 0.02  \n13. Arbidol –0.19 –0.44 –0.39 –0.34 –0.46 –0.07  \n14. Hydroxychloroquine 0.35 0.30 0.44 –0.12 0.12 0.15  \n15. Oberadilol 0.04 –0.47 –0.43 –0.37 –0.02 0.02  \n16. 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