PMC:7755033 / 8015-9213 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":"SARS-CoV-2 also encodes a non-structural replicase polyprotein that is processed by viral proteases viz. the primary viral proteinase (3CL-pro) and the papain-like protease (PL-pro). 3CL-pro (Nsp5) regulates viral replication and cleavage of Nsp4 to Nsp16 (Ziebuhr et al., 2000). This main protease is another attractive therapeutic target (Anand et al., 2003; Liu et al., 2020). PL-pro, another crucial non-structural protein, is a virally encoded cysteine protease which has a role in N-terminal processing of viral polyproteins causing release of Nsp1, Nsp2 and Nsp3 which are essential for viral replication to proceed in a correct manner (Chen et al., 2020; Harcourt et al., 2004). Recently, the structure of two critical non-structural proteins in complex Nsp10/Nsp16 has been reported. The complex is responsible for the modification of genetic material of virus in order to camouflage it with host cell DNA. This permits viral evasion and escape from the immune cells of the host, thereby perpetuating infection. Thus, targeting the Nsp10/Nsp16 complex might help in the effective combat and eradication of COVID-19 infection (https://www.anl.gov/article/new-drug-target-found-for-covid19).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"205","span":{"begin":174,"end":180},"obj":"Gene"},{"id":"206","span":{"begin":762,"end":767},"obj":"Gene"},{"id":"207","span":{"begin":1041,"end":1046},"obj":"Gene"},{"id":"208","span":{"begin":380,"end":386},"obj":"Gene"},{"id":"209","span":{"begin":0,"end":10},"obj":"Species"},{"id":"210","span":{"begin":183,"end":190},"obj":"Chemical"},{"id":"211","span":{"begin":1010,"end":1019},"obj":"Disease"},{"id":"212","span":{"begin":1115,"end":1123},"obj":"Disease"},{"id":"213","span":{"begin":1124,"end":1133},"obj":"Disease"}],"attributes":[{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Gene:43740578"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"Gene:43740578"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Gene:43740578"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"Gene:43740578"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"Tax:2697049"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D007239"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"MESH:C000657245"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D007239"},{"subj":"205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"209","pred":"source","obj":"LitCovid-PubTator"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"213","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T54","span":{"begin":0,"end":182},"obj":"Sentence"},{"id":"T55","span":{"begin":183,"end":279},"obj":"Sentence"},{"id":"T56","span":{"begin":280,"end":379},"obj":"Sentence"},{"id":"T57","span":{"begin":380,"end":686},"obj":"Sentence"},{"id":"T58","span":{"begin":687,"end":792},"obj":"Sentence"},{"id":"T59","span":{"begin":793,"end":915},"obj":"Sentence"},{"id":"T60","span":{"begin":916,"end":1020},"obj":"Sentence"},{"id":"T61","span":{"begin":1021,"end":1198},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#a993ec","default":true},{"id":"LitCovid-sentences","color":"#96ec93"}]}]}}