PMC:7755033 / 79311-80299 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":"Most of the WS phytoconstituents including Withaferin A, withanolides A, B, D and E, withanone, viscosalactone B and anaferine had positive BAS scores indicating their potential as enzyme inhibitors whereas withasomnine displayed moderate potential. This observation was further validated by the fact that most of the phytoconstituents including Withaferin A, withanolides A, B, D and E, viscosalactone B and anaferine showed potent binding to human ACE2 receptor in the nanomolar range which was about 1000× times greater than the binding of known standard reference drugs arbidol and losartan (Table 4). This finding lends support for targeted use of withanolides from WS as SARS-CoV-2 entry blocking agents by virtue of their preferential binding to human ACE2, thereby blocking or inhibiting it. Losartan, cinacalcet, hydroxychloroquine, oberadilol and poziotinib also displayed significant potential as enzyme inhibitors whereas procainamide and arbidol displayed moderate potential.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1145","span":{"begin":574,"end":581},"obj":"Chemical"},{"id":"1364","span":{"begin":12,"end":14},"obj":"Species"},{"id":"1366","span":{"begin":43,"end":55},"obj":"Chemical"},{"id":"1367","span":{"begin":57,"end":83},"obj":"Chemical"},{"id":"1368","span":{"begin":85,"end":94},"obj":"Chemical"},{"id":"1369","span":{"begin":388,"end":404},"obj":"Chemical"},{"id":"1370","span":{"begin":409,"end":418},"obj":"Chemical"},{"id":"1371","span":{"begin":934,"end":958},"obj":"Chemical"}],"attributes":[{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"MESH:C086979"},{"id":"A1364","pred":"tao:has_database_id","subj":"1364","obj":"Tax:126910"},{"id":"A1368","pred":"tao:has_database_id","subj":"1368","obj":"MESH:C560597"},{"id":"A1371","pred":"tao:has_database_id","subj":"1371","obj":"MESH:C568582"},{"subj":"1145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1364","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1366","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1367","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1368","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1369","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1370","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1371","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T785","span":{"begin":0,"end":249},"obj":"Sentence"},{"id":"T786","span":{"begin":250,"end":605},"obj":"Sentence"},{"id":"T787","span":{"begin":606,"end":799},"obj":"Sentence"},{"id":"T788","span":{"begin":800,"end":988},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T785","pred":"source","obj":"LitCovid-sentences"},{"subj":"T786","pred":"source","obj":"LitCovid-sentences"},{"subj":"T787","pred":"source","obj":"LitCovid-sentences"},{"subj":"T788","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#eccc93","default":true},{"id":"LitCovid-sentences","color":"#b293ec"}]}]}}