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PMC:7755033 / 79296-82344 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1145 589-596 Chemical denotes arbidol MESH:C086979
1147 1251-1261 Chemical denotes Withaferin
1364 27-29 Species denotes WS Tax:126910
1366 58-70 Chemical denotes Withaferin A
1367 72-98 Chemical denotes withanolides A, B, D and E
1368 100-109 Chemical denotes withanone MESH:C560597
1369 403-419 Chemical denotes viscosalactone B
1370 424-433 Chemical denotes anaferine
1371 949-973 Chemical denotes procainamide and arbidol MESH:C568582
1394 1119-1121 Species denotes WS Tax:126910
1396 1265-1276 Chemical denotes withanolide MESH:D054358
1398 1301-1313 Chemical denotes withasomnine MESH:C568582
1399 1478-1490 Chemical denotes procainamide MESH:D011342
1400 1492-1510 Chemical denotes hydroxychloroquine MESH:D006886
1401 1515-1525 Chemical denotes oberadilol
1410 1631-1633 Species denotes WS Tax:126910
1411 1698-1706 Chemical denotes Losartan
1412 1708-1720 Chemical denotes Procainamide MESH:D011342
1413 1722-1732 Chemical denotes Cinacalcet MESH:D000069449
1414 1734-1741 Chemical denotes Arbidol MESH:C086979
1415 1743-1761 Chemical denotes Hydroxychloroquine MESH:D006886
1416 1763-1773 Chemical denotes Oberadilol
1417 1775-1785 Chemical denotes Poziotinib MESH:C557213
1434 2012-2024 Chemical denotes Withaferin A
1435 2069-2080 Chemical denotes Withanolide MESH:D054358
1436 2127-2138 Chemical denotes Withanolide MESH:D054358
1437 2185-2196 Chemical denotes Withanolide MESH:D054358
1438 2243-2254 Chemical denotes Withanolide MESH:D054358
1439 2302-2311 Chemical denotes Withanone MESH:C560597
1440 2356-2370 Chemical denotes Viscosalactone
1441 2417-2426 Chemical denotes Anaferine
1442 2474-2486 Chemical denotes Withasomnine MESH:C568582
1443 2536-2544 Chemical denotes Losartan
1444 2589-2601 Chemical denotes Procainamide MESH:D011342
1445 2651-2661 Chemical denotes Cinacalcet MESH:D000069449
1446 2708-2715 Chemical denotes Arbidol MESH:C086979
1447 2766-2784 Chemical denotes Hydroxychloroquine MESH:D006886
1448 2830-2840 Chemical denotes Oberadilol
1449 2889-2899 Chemical denotes Poziotinib MESH:C557213

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T783 0-6 Sentence denotes 3.5.6.
T784 8-14 Sentence denotes As EIs
T785 15-264 Sentence denotes Most of the WS phytoconstituents including Withaferin A, withanolides A, B, D and E, withanone, viscosalactone B and anaferine had positive BAS scores indicating their potential as enzyme inhibitors whereas withasomnine displayed moderate potential.
T786 265-620 Sentence denotes This observation was further validated by the fact that most of the phytoconstituents including Withaferin A, withanolides A, B, D and E, viscosalactone B and anaferine showed potent binding to human ACE2 receptor in the nanomolar range which was about 1000× times greater than the binding of known standard reference drugs arbidol and losartan (Table 4).
T787 621-814 Sentence denotes This finding lends support for targeted use of withanolides from WS as SARS-CoV-2 entry blocking agents by virtue of their preferential binding to human ACE2, thereby blocking or inhibiting it.
T788 815-1003 Sentence denotes Losartan, cinacalcet, hydroxychloroquine, oberadilol and poziotinib also displayed significant potential as enzyme inhibitors whereas procainamide and arbidol displayed moderate potential.
T789 1004-1114 Sentence denotes Druglikeness of a compound can be predicted by comparing its structural features with those of marketed drugs.
T790 1115-1250 Sentence denotes All WS phytoconstituents showed molar lipophilicity (cLog P) <5 thereby indicating good permeability across cell membranes (Figure 2A).
T791 1251-1440 Sentence denotes Withaferin A, withanolide D, viscosalactone B and withasomnine had positive values of druglikeness which indicated that these compounds contain fragments that are present in marketed drugs.
T792 1441-1580 Sentence denotes Out of the standard reference drugs, procainamide, hydroxychloroquine and oberadilol exhibited positive scores for druglikeness (Table 14).
T793 1581-1590 Sentence denotes Table 13.
T794 1592-1787 Sentence denotes Bioactivity scores and Druglikeness of WS phytoconstituents versus FDA-approved standard reference drugs (Losartan, Procainamide, Cinacalcet, Arbidol, Hydroxychloroquine, Oberadilol, Poziotinib).
T795 1788-1790 Sentence denotes S.
T796 1791-1794 Sentence denotes No.
T797 1796-1836 Sentence denotes Ligands Parameters of bioactivity score
T798 1837-1981 Sentence denotes GPCR ligand Ion channel modulator (ICM) Kinase inhibitor (KI) Nuclear receptor ligand (NRL) Protease inhibitor (PI) Enzymeinhibitor (EI)  
T799 1982-2007 Sentence denotes                  
T800 2008-2010 Sentence denotes 1.
T801 2012-2064 Sentence denotes Withaferin A 0.07 0.14 –0.49 0.76 0.15 0.94  
T802 2065-2067 Sentence denotes 2.
T803 2069-2122 Sentence denotes Withanolide A 0.04 0.32 –0.43 0.71 0.15 0.86  
T804 2123-2125 Sentence denotes 3.
T805 2127-2180 Sentence denotes Withanolide B 0.07 0.24 –0.47 0.79 0.15 0.76  
T806 2181-2183 Sentence denotes 4.
T807 2185-2238 Sentence denotes Withanolide D 0.05 0.30 –0.50 0.73 0.16 1.07  
T808 2239-2241 Sentence denotes 5.
T809 2243-2297 Sentence denotes Withanolide E –0.70 0.16 –0.50 0.61 0.06 0.89  
T810 2298-2300 Sentence denotes 6.
T811 2302-2351 Sentence denotes Withanone 0.00 0.27 –0.38 0.71 0.12 0.78  
T812 2352-2354 Sentence denotes 7.
T813 2356-2412 Sentence denotes Viscosalactone B 0.03 0.04 –0.51 0.78 0.19 0.84  
T814 2413-2415 Sentence denotes 8.
T815 2417-2469 Sentence denotes Anaferine –0.08 0.17 –0.60 –0.58 –0.14 0.08  
T816 2470-2472 Sentence denotes 9.
T817 2474-2530 Sentence denotes Withasomnine –0.49 –0.43 0.58 –0.10 –0.58 –0.17  
T818 2531-2534 Sentence denotes 10.
T819 2536-2583 Sentence denotes Losartan 1.06 0.16 0.03 0.01 0.33 0.44  
T820 2584-2587 Sentence denotes 11.
T821 2589-2645 Sentence denotes Procainamide –0.09 0.01 –0.10 –0.70 –0.20 –0.04  
T822 2646-2649 Sentence denotes 12.
T823 2651-2702 Sentence denotes Cinacalcet 0.22 0.15 –0.0.8 0.00 0.17 0.02  
T824 2703-2706 Sentence denotes 13.
T825 2708-2760 Sentence denotes Arbidol –0.19 –0.44 –0.39 –0.34 –0.46 –0.07  
T826 2761-2764 Sentence denotes 14.
T827 2766-2824 Sentence denotes Hydroxychloroquine 0.35 0.30 0.44 –0.12 0.12 0.15  
T828 2825-2828 Sentence denotes 15.
T829 2830-2883 Sentence denotes Oberadilol 0.04 –0.47 –0.43 –0.37 –0.02 0.02  
T830 2884-2887 Sentence denotes 16.
T831 2889-2941 Sentence denotes Poziotinib 0.04 –0.17 0.53 –0.35 –0.27 0.01  
T832 2942-2955 Sentence denotes Rule: BAS >0:
T833 2956-2963 Sentence denotes Active;
T834 2964-2977 Sentence denotes BAS –5.0–0.0:
T835 2978-3028 Sentence denotes Moderately active, moderately active and inactive.
T836 3029-3038 Sentence denotes BAS ≤5.0:
T837 3039-3048 Sentence denotes Inactive;