PMC:7755033 / 78497-79294 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1309","span":{"begin":468,"end":473},"obj":"Gene"},{"id":"1310","span":{"begin":474,"end":477},"obj":"Gene"},{"id":"1311","span":{"begin":490,"end":493},"obj":"Gene"},{"id":"1312","span":{"begin":439,"end":442},"obj":"Gene"},{"id":"1313","span":{"begin":392,"end":395},"obj":"Gene"},{"id":"1314","span":{"begin":380,"end":390},"obj":"Species"},{"id":"1315","span":{"begin":407,"end":415},"obj":"Species"},{"id":"1316","span":{"begin":457,"end":467},"obj":"Species"},{"id":"1317","span":{"begin":0,"end":12},"obj":"Chemical"},{"id":"1318","span":{"begin":14,"end":26},"obj":"Chemical"},{"id":"1319","span":{"begin":42,"end":51},"obj":"Chemical"},{"id":"1320","span":{"begin":56,"end":70},"obj":"Chemical"},{"id":"1321","span":{"begin":167,"end":176},"obj":"Chemical"},{"id":"1322","span":{"begin":181,"end":193},"obj":"Chemical"},{"id":"1323","span":{"begin":275,"end":287},"obj":"Chemical"},{"id":"1324","span":{"begin":317,"end":330},"obj":"Chemical"},{"id":"1325","span":{"begin":590,"end":598},"obj":"Chemical"},{"id":"1326","span":{"begin":600,"end":610},"obj":"Chemical"},{"id":"1327","span":{"begin":615,"end":633},"obj":"Chemical"},{"id":"1328","span":{"begin":696,"end":708},"obj":"Chemical"},{"id":"1329","span":{"begin":710,"end":717},"obj":"Chemical"},{"id":"1330","span":{"begin":719,"end":729},"obj":"Chemical"},{"id":"1331","span":{"begin":734,"end":744},"obj":"Chemical"}],"attributes":[{"id":"A1309","pred":"tao:has_database_id","subj":"1309","obj":"Gene:43740578"},{"id":"A1310","pred":"tao:has_database_id","subj":"1310","obj":"Gene:43740578"},{"id":"A1311","pred":"tao:has_database_id","subj":"1311","obj":"Gene:5131"},{"id":"A1312","pred":"tao:has_database_id","subj":"1312","obj":"Gene:5131"},{"id":"A1313","pred":"tao:has_database_id","subj":"1313","obj":"Gene:5131"},{"id":"A1314","pred":"tao:has_database_id","subj":"1314","obj":"Tax:2697049"},{"id":"A1315","pred":"tao:has_database_id","subj":"1315","obj":"Tax:694009"},{"id":"A1316","pred":"tao:has_database_id","subj":"1316","obj":"Tax:2697049"},{"id":"A1318","pred":"tao:has_database_id","subj":"1318","obj":"MESH:D054358"},{"id":"A1319","pred":"tao:has_database_id","subj":"1319","obj":"MESH:C560597"},{"id":"A1322","pred":"tao:has_database_id","subj":"1322","obj":"MESH:C568582"},{"id":"A1323","pred":"tao:has_database_id","subj":"1323","obj":"MESH:D054358"},{"id":"A1325","pred":"tao:has_database_id","subj":"1325","obj":"MESH:D019808"},{"id":"A1326","pred":"tao:has_database_id","subj":"1326","obj":"MESH:D000069449"},{"id":"A1327","pred":"tao:has_database_id","subj":"1327","obj":"MESH:D006886"},{"id":"A1328","pred":"tao:has_database_id","subj":"1328","obj":"MESH:D011342"},{"id":"A1329","pred":"tao:has_database_id","subj":"1329","obj":"MESH:C086979"},{"id":"A1331","pred":"tao:has_database_id","subj":"1331","obj":"MESH:C557213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Withaferin A, withanolides A, B, D and E, withanone and viscosalactone B had positive BAS scores indicating their potential as protease inhibitors. On the other hand, anaferine and withasomnine were found to have moderate activity as protease inhibitors. Interestingly, most withanolides especially withanolide B and withanolide A showed potent binding to papain like protease of SARS-CoV-2 (PDB ID: 6W9C), SARS-CoV 3CL-pro main protease (PDB ID: IP9U) and SARS-CoV-2 Nsp10/Nsp-16 complex (PDB ID: 6W75) thus supporting their role as potential viral protease inhibitors. On the other hand, losartan, cinacalcet and hydroxychloroquine also displayed positive values as protease inhibitors whereas procainamide, arbidol, oberadilol and poziotinib displayed moderate potential as protease inhibitors."}

{"project":"LitCovid-sentences","denotations":[{"id":"T777","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T778","span":{"begin":148,"end":254},"obj":"Sentence"},{"id":"T779","span":{"begin":255,"end":399},"obj":"Sentence"},{"id":"T780","span":{"begin":400,"end":497},"obj":"Sentence"},{"id":"T781","span":{"begin":498,"end":570},"obj":"Sentence"},{"id":"T782","span":{"begin":571,"end":797},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Withaferin A, withanolides A, B, D and E, withanone and viscosalactone B had positive BAS scores indicating their potential as protease inhibitors. On the other hand, anaferine and withasomnine were found to have moderate activity as protease inhibitors. Interestingly, most withanolides especially withanolide B and withanolide A showed potent binding to papain like protease of SARS-CoV-2 (PDB ID: 6W9C), SARS-CoV 3CL-pro main protease (PDB ID: IP9U) and SARS-CoV-2 Nsp10/Nsp-16 complex (PDB ID: 6W75) thus supporting their role as potential viral protease inhibitors. On the other hand, losartan, cinacalcet and hydroxychloroquine also displayed positive values as protease inhibitors whereas procainamide, arbidol, oberadilol and poziotinib displayed moderate potential as protease inhibitors."}