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PMC:7755033 / 70087-71023 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
916 832-838 Gene denotes PL-pro Gene:43740578
917 849-853 Gene denotes ACE2 Gene:59272
918 340-343 Gene denotes PDB Gene:5131
919 94-97 Gene denotes PDB Gene:5131
920 306-316 Species denotes SARS-CoV-2 Tax:2697049
921 443-451 Species denotes SARS-CoV Tax:694009
922 456-466 Species denotes SARS-CoV-2 Tax:2697049
923 658-668 Species denotes SARS-CoV-2 Tax:2697049
924 843-848 Species denotes human Tax:9606
925 869-871 Species denotes WS Tax:126910
926 369-376 Chemical denotes 3CL-pro
927 684-700 Chemical denotes viscosalactone B

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T618 102-347 Sentence denotes 1P9U; Table 9), whereas anaferine was found to interact with the active site residues Cys145, Glu166, Ser144, Met165, His163, His164, Gln189, Asp187, Arg188, Met49 and His41 present at the active site of SARS-CoV-2 main protease 3CL-pro (PDB ID:
T619 348-364 Sentence denotes 6LU7; Table 10).
T620 365-551 Sentence denotes The 3CL-pro active site has been found to be evolutionarily conserved between SARS-CoV and SARS-CoV-2 (Báez-Santos et al., 2015; Chen et al., 2020; Guy et al., 2005; Zhang et al., 2020).
T621 552-744 Sentence denotes In the same manner, the other seven phytoconstituents also displayed potent binding to the active site of SARS-CoV-2 3CL-pro except viscosalactone B as predicted by AutoDock vina and iGEMDOCK.
T622 745-815 Sentence denotes The active site residues have been written in bold in Tables 9 and 10.
T623 816-936 Sentence denotes As far as viral PL-pro and human ACE2 are concerned, WS phytoconstituents displayed allosteric binding to these enzymes.