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PMC:7755033 / 6367-8014 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
175 423-427 Gene denotes ACE2 Gene:59272
176 814-818 Gene denotes ACE2 Gene:59272
177 1179-1183 Gene denotes ACE2 Gene:59272
178 1274-1279 Gene denotes Spike Gene:43740568
179 1480-1484 Gene denotes ACE2 Gene:59272
180 53-58 Species denotes human Tax:9606
181 70-74 Species denotes CoVs Tax:11118
182 341-346 Species denotes human Tax:9606
183 358-371 Species denotes coronaviruses Tax:11118
184 688-698 Species denotes SARS-CoV-2 Tax:2697049
185 758-768 Species denotes SARS-CoV-2 Tax:2697049
186 808-813 Species denotes human Tax:9606
187 967-977 Species denotes SARS-CoV-2 Tax:2697049
188 1173-1178 Species denotes human Tax:9606
189 124-134 Chemical denotes nucleoside MESH:D009705
190 144-154 Chemical denotes remdesivir MESH:C000606551
191 156-176 Chemical denotes tenofovir disoproxil MESH:D000068698
192 184-194 Chemical denotes umifenovir MESH:C086979
193 196-203 Chemical denotes arbidol MESH:C086979
194 209-219 Chemical denotes lamivudine MESH:D019259
195 221-224 Chemical denotes 3TC MESH:D019259

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T46 0-244 Sentence denotes Several antiviral therapies have been identified for human pathogenic CoVs including synthetic inhibitors of neuraminidase, nucleoside analogs, remdesivir, tenofovir disoproxil (TDF), umifenovir (arbidol) and lamivudine (3TC) (Li et al., 2005).
T47 245-387 Sentence denotes Studies involving identification of cellular receptors that facilitate the binding and entry of human associated coronaviruses have been done.
T48 388-630 Sentence denotes Angiotensin I-converting enzyme 2 (ACE2) is a membrane bound aminopeptidase expressed in renal, cardiovascular, vascular and testicular tissue, as well as the small intestine (Donoghue et al., 2000; Hamming et al., 2004; Harmer et al., 2002).
T49 631-782 Sentence denotes It has been shown to be a co-receptor for viral entry of SARS-CoV-2 with increasing evidence that it has a significant role in SARS-CoV-2 pathogenesis.
T50 783-966 Sentence denotes Therefore, targeting the human ACE2 receptor might block the entry and the subsequent pathophysiology of the virus and is one of the premises of the present study (Zhou et al., 2020).
T51 967-1273 Sentence denotes SARS-CoV-2 entry into host cells is mediated by transmembrane spike(S) like glycoprotein that causes neutralization of antibodies, facilitates the projection of homotrimers from the viral surface, binds to human ACE2 receptor, and finally mediates membrane fusion and transport (Tortorici & Veesler, 2019).
T52 1274-1434 Sentence denotes Spike (S) protein initially cleaves itself into two functional subunits (S1 and S2) which remain non-covalently bound to each other in a prefusion conformation.
T53 1435-1647 Sentence denotes The S1 subunit is responsible for binding to ACE2, whereas S2 subunit has role in viral and host cell membrane fusion (Belouzard et al., 2009; Bosch et al., 2003; Burkard et al., 2014; Kirchdoerfer et al., 2016).