PMC:7755033 / 39353-39797 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"754","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"755","span":{"begin":287,"end":291},"obj":"Gene"},{"id":"767","span":{"begin":50,"end":55},"obj":"Species"},{"id":"768","span":{"begin":281,"end":286},"obj":"Species"},{"id":"774","span":{"begin":21,"end":23},"obj":"Species"},{"id":"776","span":{"begin":93,"end":104},"obj":"Chemical"},{"id":"777","span":{"begin":109,"end":120},"obj":"Chemical"},{"id":"778","span":{"begin":125,"end":136},"obj":"Chemical"},{"id":"779","span":{"begin":141,"end":155},"obj":"Chemical"},{"id":"780","span":{"begin":160,"end":170},"obj":"Chemical"},{"id":"781","span":{"begin":175,"end":184},"obj":"Chemical"},{"id":"782","span":{"begin":187,"end":198},"obj":"Chemical"},{"id":"783","span":{"begin":203,"end":212},"obj":"Chemical"},{"id":"784","span":{"begin":215,"end":227},"obj":"Chemical"},{"id":"785","span":{"begin":311,"end":313},"obj":"Chemical"},{"id":"786","span":{"begin":387,"end":394},"obj":"Chemical"},{"id":"787","span":{"begin":405,"end":407},"obj":"Chemical"}],"attributes":[{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:59272"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:59272"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"Tax:9606"},{"id":"A768","pred":"tao:has_database_id","subj":"768","obj":"Tax:9606"},{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"Tax:126910"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:D054358"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:D054358"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"MESH:D054358"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"MESH:D054358"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"MESH:C560597"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"MESH:C568582"},{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"MESH:C086979"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ng affinities of the WS phytoconstituents for the human ACE2 receptor decreased in the order withanolide B \u003e withanolide A \u003e withanolide E \u003e viscosalactone B \u003e withaferin A \u003e anaferine \u003e withanolide D \u003e withanone \u003e withasomnine. Withanolide B exhibited a 1000× stronger binding to human ACE2 receptor (Table 5; BE: −10.21 kcal/mol, Kd: 32.78 nM) as compared to standard reference drugs, arbidol (Table 5; BE: −6.69 kcal/mol, Kd: 12.47 µM) and l"}

{"project":"LitCovid-sentences","denotations":[{"id":"T406","span":{"begin":229,"end":335},"obj":"Sentence"},{"id":"T407","span":{"begin":336,"end":428},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ng affinities of the WS phytoconstituents for the human ACE2 receptor decreased in the order withanolide B \u003e withanolide A \u003e withanolide E \u003e viscosalactone B \u003e withaferin A \u003e anaferine \u003e withanolide D \u003e withanone \u003e withasomnine. Withanolide B exhibited a 1000× stronger binding to human ACE2 receptor (Table 5; BE: −10.21 kcal/mol, Kd: 32.78 nM) as compared to standard reference drugs, arbidol (Table 5; BE: −6.69 kcal/mol, Kd: 12.47 µM) and l"}