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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":"3.2.3. Blood–brain barrier (BBB) penetration\nAn important consideration for drug candidates is their ability to cross the BBB. All of the chosen WS phytoconstituents displayed positive results for BBB penetration except withanolide E. In case of standard reference drugs, only losartan displayed inability to penetrate the BBB (Table 4).","divisions":[{"label":"label","span":{"begin":0,"end":6}},{"label":"title","span":{"begin":8,"end":45}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"698","span":{"begin":146,"end":148},"obj":"Species"},{"id":"699","span":{"begin":221,"end":234},"obj":"Chemical"},{"id":"700","span":{"begin":278,"end":286},"obj":"Chemical"},{"id":"701","span":{"begin":297,"end":306},"obj":"Disease"}],"attributes":[{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"Tax:126910"},{"id":"A700","pred":"tao:has_database_id","subj":"700","obj":"MESH:D019808"},{"id":"A701","pred":"tao:has_database_id","subj":"701","obj":"MESH:D007319"},{"subj":"698","pred":"source","obj":"LitCovid-PubTator"},{"subj":"699","pred":"source","obj":"LitCovid-PubTator"},{"subj":"700","pred":"source","obj":"LitCovid-PubTator"},{"subj":"701","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T388","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T389","span":{"begin":8,"end":45},"obj":"Sentence"},{"id":"T390","span":{"begin":46,"end":127},"obj":"Sentence"},{"id":"T391","span":{"begin":128,"end":235},"obj":"Sentence"},{"id":"T392","span":{"begin":236,"end":338},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T388","pred":"source","obj":"LitCovid-sentences"},{"subj":"T389","pred":"source","obj":"LitCovid-sentences"},{"subj":"T390","pred":"source","obj":"LitCovid-sentences"},{"subj":"T391","pred":"source","obj":"LitCovid-sentences"},{"subj":"T392","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93d5ec","default":true},{"id":"LitCovid-sentences","color":"#ece893"}]}]}}