PMC:7755033 / 26965-27626 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
471	93-106	Chemical	denotes	heme-thiolate

Id	Subject	Object	Predicate	Lexical cue
T234	0-148	Sentence	denotes	Most of the FDA-approved drugs are known to be metabolized by a ubiquitous protein family of heme-thiolate enzymes known as cytochrome P450s (CYPs).
T235	149-397	Sentence	denotes	Regioselectivity-WebPredictor (http://reccr.chem.rpi.edu/Software/RS-WebPredicto/) is an algorithm for accurate prediction of isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOM) on drug like molecules (Nebert & Russell, 2002).
T236	398-661	Sentence	denotes	This is the very first repository that makes metabolic predictions for nine isozymes (1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4) available to the public and uses models trained on the largest set of CYP substrate and metabolite data (Zaretzki et al., 2013).