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PMC:7755033 / 258-2005 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
29 506-510 Gene denotes ACE2 Gene:59272
30 809-813 Gene denotes ACE2 Gene:59272
31 1317-1322 Gene denotes spike Gene:43740568
32 847-852 Gene denotes spike Gene:43740568
33 0-13 Species denotes Coronaviruses Tax:11118
34 48-53 Species denotes human Tax:9606
35 277-306 Species denotes Withania somnifera (L.) Dunal Tax:126910
36 469-479 Species denotes SARS-CoV-2 Tax:2697049
37 500-505 Species denotes human Tax:9606
38 803-808 Species denotes human Tax:9606
39 824-827 Species denotes SAR Tax:2698737
40 828-831 Species denotes CoV Tax:11118
41 836-846 Species denotes SARS-CoV-2 Tax:2697049
42 891-901 Species denotes SARS-CoV-2 Tax:2697049
43 1125-1128 Species denotes SAR Tax:2698737
44 1306-1316 Species denotes SARS-CoV-2 Tax:2697049
45 308-310 Species denotes WS Tax:126910
46 430-432 Species denotes WS Tax:126910
47 754-756 Species denotes WS Tax:126910
48 1542-1544 Species denotes WS Tax:126910
49 1166-1172 Chemical denotes oxygen MESH:D010100
50 1186-1197 Chemical denotes withanolide MESH:D054358
51 65-74 Disease denotes infection MESH:D007239
52 169-177 Disease denotes COVID-19 MESH:C000657245
53 1738-1746 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-137 Sentence denotes Coronaviruses are etiological agents of extreme human and animal infection resulting in abnormalities primarily in the respiratory tract.
T8 138-276 Sentence denotes Presently, there is no defined COVID-19 intervention and clinical trials of prospective therapeutic agents are still in the nascent stage.
T9 277-357 Sentence denotes Withania somnifera (L.) Dunal (WS), is an important medicinal plant in Ayurveda.
T10 358-544 Sentence denotes The present study aimed to evaluate the antiviral potential of selected WS phytoconstituents against the novel SARS-CoV-2 target proteins and human ACE2 receptor using in silico methods.
T11 545-700 Sentence denotes Most of the phytoconstituents displayed good absorption and transport kinetics and were also found to display no associated mutagenic or adverse effect(s).
T12 701-912 Sentence denotes Molecular docking analyses revealed that most of the WS phytoconstituents exhibited potent binding to human ACE2 receptor, SAR-CoV and SARS-CoV-2 spike glycoproteins as well as the two main SARS-CoV-2 proteases.
T13 913-1007 Sentence denotes Most of the phytoconstituents were predicted to undergo Phase-I metabolism prior to excretion.
T14 1008-1124 Sentence denotes All phytoconstituents had favorable bioactivity scores with respect to various receptor proteins and target enzymes.
T15 1125-1272 Sentence denotes SAR analysis revealed that the number of oxygen atoms in the withanolide backbone and structural rearrangements were crucial for effective binding.
T16 1273-1526 Sentence denotes Molecular simulation analyses of SARS-CoV-2 spike protein and papain-like protease with Withanolides A and B, respectively, displayed a stability profile at 300 K and constant RMSDs of protein side chains and Cα atoms throughout the simulation run time.
T17 1527-1747 Sentence denotes In a nutshell, WS phytoconstituents warrant further investigations in vitro and in vivo to unravel their molecular mechanism(s) and modes of action for their future development as novel antiviral agents against COVID-19.