PMC:7755033 / 17667-18040 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T149","span":{"begin":0,"end":168},"obj":"Sentence"},{"id":"T150","span":{"begin":169,"end":289},"obj":"Sentence"},{"id":"T151","span":{"begin":290,"end":361},"obj":"Sentence"},{"id":"T152","span":{"begin":363,"end":369},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"With a reduction in polar surface area, permeation increases and with the increase in number of rotatable bonds permeation decreases significantly (Veber et al., 2002). The following two criteria should be met by a potential drug candidate in order to obey Veber rules:≤10 rotatable bonds;\nPolar surface area ≤140Å2 (or 12 or fewer H-bond donors and acceptors).\n\n2.2.3. Gh"}