| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T145 |
0-6 |
Sentence |
denotes |
2.2.2. |
| T146 |
8-18 |
Sentence |
denotes |
Veber rule |
| T147 |
19-90 |
Sentence |
denotes |
For oral bioavailability, membrane permeability is an important factor. |
| T148 |
91-227 |
Sentence |
denotes |
Polar surface area and number of rotatable bonds are two critical considerations for a compound to behave as a potential drug candidate. |
| T149 |
228-396 |
Sentence |
denotes |
With a reduction in polar surface area, permeation increases and with the increase in number of rotatable bonds permeation decreases significantly (Veber et al., 2002). |
| T150 |
397-517 |
Sentence |
denotes |
The following two criteria should be met by a potential drug candidate in order to obey Veber rules:≤10 rotatable bonds; |
| T151 |
518-589 |
Sentence |
denotes |
Polar surface area ≤140Å2 (or 12 or fewer H-bond donors and acceptors). |
