PMC:7755033 / 109375-110687 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1113 660-665 Gene denotes spike Gene:43740568
1122 649-659 Species denotes SARS-CoV-2 Tax:2697049
1359 443-447 Gene denotes ACE2 Gene:59272
1361 437-442 Species denotes human Tax:9606
2096 795-800 Gene denotes Nsp10 Gene:43740578
2097 801-804 Gene denotes Nsp Gene:43740578
2099 594-599 Gene denotes spike Gene:43740568
2101 458-466 Species denotes SARS-CoV Tax:694009
2102 471-481 Species denotes SARS-CoV-2 Tax:2697049
2103 585-593 Species denotes SARS-CoV Tax:694009
2105 714-722 Species denotes SARS-CoV Tax:694009
2106 784-794 Species denotes SARS-CoV-2 Tax:2697049
2107 1071-1089 Species denotes Withania somnifera Tax:126910
2108 1245-1255 Species denotes SARS-CoV-2 Tax:2697049
2109 414-416 Species denotes WS Tax:126910
2110 975-977 Species denotes WS Tax:126910
2111 0-10 Chemical denotes Nelfinavir MESH:D019888
2112 15-24 Chemical denotes lopinavir MESH:D061466
2113 134-143 Chemical denotes Lopinavir MESH:D061466
2114 148-157 Chemical denotes ritonavir MESH:D019438
2115 274-284 Chemical denotes nelfinavir MESH:D019888
2116 289-298 Chemical denotes lopinavir MESH:D061466
2117 392-404 Chemical denotes withanolides MESH:D054358
2118 885-897 Chemical denotes withanolides MESH:D054358
2119 910-919 Chemical denotes withanone MESH:C560597
2120 68-81 Disease denotes HIV infection MESH:D015658
2121 230-234 Disease denotes MERS MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1106 0-133 Sentence denotes Nelfinavir and lopinavir are viral protease inhibitors used against HIV infection but are reported to possess high cytotoxic effects.
T1107 134-329 Sentence denotes Lopinavir and ritonavir are viral protease inhibitors recommended for the treatment of SARS and MERS having similar mechanisms of action as nelfinavir and lopinavir. (Miyamoto and Kollman, 1992).
T1108 330-500 Sentence denotes To elucidate the binding affinity, docking studies of various withanolides found in WS were carried out on human ACE2 receptor, SARS-CoV and SARS-CoV-2 specific proteins.
T1109 501-637 Sentence denotes Among various phytoconstituents, withanolide A displayed strong binding affinity to SARS-CoV spike glycoprotein (BE: −9.78 kcal/mol, Kd:
T1110 638-703 Sentence denotes 67.23 nM), SARS-CoV-2 spike glycoprotein (BE: −7.18 kcal/mol, Kd:
T1111 704-768 Sentence denotes 5.48 µM), SARS-CoV 3CL-pro main protease (BE:-8.93 kcal/mol, Kd:
T1112 769-841 Sentence denotes 285.01 nM) and SARS-CoV-2 Nsp10/Nsp-16 complex (BE: −10.38 kcal/mol, Kd:
T1113 842-852 Sentence denotes 24.67 nM).
T1114 853-978 Sentence denotes On the basis of binding energy, withanolides A and B and withanone were found to be the most effective phytocomponents in WS.
T1115 979-1312 Sentence denotes The present study reports for the first time the antiviral efficacy of medicinal herbs like Withania somnifera that form the crux of Ayurveda, the Indian traditional system of medicine as a viable alternative to chemosynthetic drugs for preventing/blocking entry of SARS-CoV-2 into host cells and also inhibiting viral main protease.