PMC:7755033 / 107247-109374 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2046 1635-1639 Gene denotes ACE2 Gene:59272
2047 1893-1897 Gene denotes ACE2 Gene:59272
2048 1271-1275 Species denotes CoVs Tax:11118
2049 1629-1634 Species denotes Human Tax:9606
2050 1723-1731 Species denotes SARS-CoV Tax:694009
2051 1736-1746 Species denotes SARS-CoV-2 Tax:2697049
2052 1837-1850 Species denotes coronaviruses Tax:11118
2053 1972-1985 Species denotes coronaviruses Tax:11118
2054 22-24 Species denotes WS Tax:126910
2055 301-303 Species denotes WS Tax:126910
2056 1190-1192 Species denotes WS Tax:126910
2057 1788-1793 Gene denotes spike Gene:43740568
2058 352-356 Chemical denotes ADME
2059 456-462 Chemical denotes Caco-2
2060 477-486 Chemical denotes anaferine
2061 491-503 Chemical denotes withasomnine MESH:C568582
2062 542-548 Chemical denotes Caco-2
2063 584-589 Chemical denotes Caco-
2064 1260-1267 Chemical denotes 3CL-pro
2065 966-980 Disease denotes genetic damage MESH:D030342
2066 1100-1114 Disease denotes carcinogenesis MESH:D063646
2067 1372-1381 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1094 0-251 Sentence denotes Prior to selection of WS phytoconstituents, their ADMET properties were calculated using online database (admetSAR), which provides latest and most inclusive manually created data for various chemicals with known ADMET properties (Cheng et al., 2012).
T1095 252-435 Sentence denotes Interestingly, in the present study, most of the WS phytoconstituents exhibited positive results of ADME and none of the phytoconstituents were predicted to have any mutagenic effect.
T1096 436-562 Sentence denotes Further, in case of Caco-2 permeability, anaferine and withasomnine exhibited positive results indicating Caco-2 permeability.
T1097 563-848 Sentence denotes Positive results for Caco-2 indicate good permeability characteristics of compounds under evaluation since Caco-2 cells express a number of transporter and efflux proteins as well as Phase II conjugation enzymes for metabolic transformation of test substances (van Breemen & Li, 2005).
T1098 849-1054 Sentence denotes Ames test is a short-term bacterial reverse mutation assay used for evaluating compounds for their ability to induce genetic damage and frame shift mutations (Ames et al., 1975; Mortelmans & Zeiger, 2000).
T1099 1055-1133 Sentence denotes Mutagenic effects bear a close connection to carcinogenesis (Xu et al., 2012).
T1100 1134-1255 Sentence denotes Interestingly, in the present study, none of the chosen WS phytoconstituents were predicted to have any mutagenic effect.
T1101 1256-1462 Sentence denotes The 3CL-pro of CoVs is necessary for the proteolytic maturation of the virus and a potential drug target to prevent infection from spreading by inhibiting the cleavage of viral proteins (Tian et al., 2015).
T1102 1463-1628 Sentence denotes Therefore, inhibition of such proteases which have a role in virus replication are often used as treatment strategies in antiviral drug therapeutics (Delaney, 2004).
T1103 1629-1769 Sentence denotes Human ACE2 expression in the airway epithelia appears to be critical as an entry receptor for SARS-CoV and SARS-CoV-2 (Morris et al., 1998).
T1104 1770-1986 Sentence denotes The transmembrane spike (S) glycoprotein present on the surface of coronaviruses facilitates their entry into the cell via ACE2 and is considered to be another prime target for antiviral agents against coronaviruses.
T1105 1987-2127 Sentence denotes These findings have implications for understanding disease pathogenesis and opportunity to identify potential drug candidates for treatment.