| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1087 |
0-152 |
Sentence |
denotes |
Generally, an orally active drug candidate cannot have more than one violation of Lipinski’s criteria otherwise it might compromise its bioavailability. |
| T1088 |
153-255 |
Sentence |
denotes |
Good drug candidates with MW < 500 can be administered easily and are readily diffusible and absorbed. |
| T1089 |
256-384 |
Sentence |
denotes |
For optimal biological activity, the number of rotatable bonds should be <10, indicating a higher amount of molecular stability. |
| T1090 |
385-557 |
Sentence |
denotes |
Similarly, total polar surface area (TPSA) should coincide with hydrogen bonding of a molecule and characterize the delivery properties of the drug which should be <160 Å2. |
| T1091 |
558-675 |
Sentence |
denotes |
For a high oral bioavailability, the absorption rate determined from TPSA should be >50% (Balakrishnan et al., 2014). |
| T1092 |
676-870 |
Sentence |
denotes |
Interestingly, none of the phytocomponents of WS exhibited Lipinski’s violation, however, the standard drugs cinacalcet and poziotinib displayed 1 violation of Lipinski’s rule of five (Table 2). |
| T1093 |
871-1027 |
Sentence |
denotes |
In addition, the selected phytoconstituents exhibited no violations of Veber, Egan and Muegge filters thereby indicating their druglike character (Table 3). |
