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PMC:7736111 / 98704-100415 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2333 1150-1151 Gene denotes N Gene:43740575
2334 997-998 Gene denotes N Gene:43740575
2335 171-176 Species denotes woman Tax:9606
2336 330-338 Species denotes patients Tax:9606
2337 468-476 Species denotes patients Tax:9606
2338 683-691 Species denotes patients Tax:9606
2339 890-898 Species denotes patients Tax:9606
2340 1325-1333 Species denotes patients Tax:9606
2341 1535-1548 Species denotes coronaviruses Tax:11118
2342 966-976 Species denotes SARS-CoV-2 Tax:2697049
2343 674-682 Disease denotes COVID-19 MESH:C000657245
2344 1316-1324 Disease denotes COVID-19 MESH:C000657245
2345 1702-1710 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T581 0-129 Sentence denotes Contrary to B cell activation, some studies have shown lower antibody durability in both mild and severe cases (Yu et al., 2020).
T582 130-284 Sentence denotes In a longitudinal study on a 26-year-old woman with a moderate disease condition, antibody response disappeared within three months (Liu A. et al., 2020).
T583 285-486 Sentence denotes In a sizable cohort of samples, asymptomatic patients (n = 37 with median age 41 years) had relatively lower durability of the IgG and IgM antibodies in comparison to the symptomatic patients (n = 37).
T584 487-600 Sentence denotes Further, the viral shedding in the asymptomatic group was higher than the symptomatic group (Long et al., 2020b).
T585 601-803 Sentence denotes Similarly, Ibarrondo et al. has shown the same antibody durability in 34 COVID-19 patients with a mean age of 43 years when studied longitudinally for a period of upto 4 months (Ibarrondo et al., 2020).
T586 804-925 Sentence denotes The authors found a significant decline in IgG antibodies in the sera of convalescent patients with mostly mild symptoms.
T587 926-1091 Sentence denotes A declining trend was seen for multiple SARS-CoV-2 antibodies like IgG N, IgM, IgG S1, and IgA S1 in the longitudinal analysis (n = 487) (Gudbjartsson et al., 2020).
T588 1092-1243 Sentence denotes In another longitudinal study, the disappearance of S and N protein-specific antibodies was observed within 3 months of recovery (Liu A. et al., 2020).
T589 1244-1572 Sentence denotes Based on these reports, we can infer that the antibody response in some COVID-19 patients may not be long-lasting, which poses a challenge for antibody-based therapy and vaccine research—further, these data caution towards chances of reinfection, as shown to be the case with other seasonal coronaviruses (Edridge et al., 2020).
T590 1573-1711 Sentence denotes However, larger cohort size and longer time frame longitudinal studies are needed to find the durability of antibody response in COVID-19.