PMC:7736111 / 88154-88681 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Both CD4+ and CD8+ T cells also exhibit dysregulated response (Qin et al., 2020). Decreased levels of CD4+ regulatory cells as marked by CD3+ CD4+ CD25+ CD127low+ population was found in severe cases. Similarly, the study found decreased CD8+ suppressor T cells (CD3+, CD8+, CD28+) in severe cases. Overall, more comprehensive studies are warranted with larger cohort size, to profile local vs systemic T cell response and persistence simultaneously, and correlate these responses with disease severity in age-matched patients.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"2184","span":{"begin":5,"end":8},"obj":"Gene"},{"id":"2185","span":{"begin":14,"end":17},"obj":"Gene"},{"id":"2186","span":{"begin":102,"end":105},"obj":"Gene"},{"id":"2187","span":{"begin":142,"end":145},"obj":"Gene"},{"id":"2188","span":{"begin":153,"end":158},"obj":"Gene"},{"id":"2189","span":{"begin":238,"end":241},"obj":"Gene"},{"id":"2190","span":{"begin":269,"end":272},"obj":"Gene"},{"id":"2191","span":{"begin":518,"end":526},"obj":"Species"}],"attributes":[{"id":"A2184","pred":"tao:has_database_id","subj":"2184","obj":"Gene:920"},{"id":"A2185","pred":"tao:has_database_id","subj":"2185","obj":"Gene:925"},{"id":"A2186","pred":"tao:has_database_id","subj":"2186","obj":"Gene:920"},{"id":"A2187","pred":"tao:has_database_id","subj":"2187","obj":"Gene:920"},{"id":"A2188","pred":"tao:has_database_id","subj":"2188","obj":"Gene:3575"},{"id":"A2189","pred":"tao:has_database_id","subj":"2189","obj":"Gene:925"},{"id":"A2190","pred":"tao:has_database_id","subj":"2190","obj":"Gene:925"},{"id":"A2191","pred":"tao:has_database_id","subj":"2191","obj":"Tax:9606"},{"subj":"2184","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2185","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2186","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2187","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2188","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2189","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2190","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2191","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T515","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T516","span":{"begin":82,"end":200},"obj":"Sentence"},{"id":"T517","span":{"begin":201,"end":298},"obj":"Sentence"},{"id":"T518","span":{"begin":299,"end":527},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T515","pred":"source","obj":"LitCovid-sentences"},{"subj":"T516","pred":"source","obj":"LitCovid-sentences"},{"subj":"T517","pred":"source","obj":"LitCovid-sentences"},{"subj":"T518","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecd293","default":true},{"id":"LitCovid-sentences","color":"#b893ec"}]}]}}