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PMC:7736111 / 87-1644 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1486-1510 Phenotype denotes impaired T cell function http://purl.obolibrary.org/obo/HP_0005435

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
19 62-72 Species denotes SARS-CoV-2 Tax:2697049
20 115-123 Species denotes patients Tax:9606
21 149-157 Species denotes patients Tax:9606
22 466-474 Species denotes patients Tax:9606
23 666-674 Species denotes patients Tax:9606
24 1171-1181 Species denotes SARS-CoV-2 Tax:2697049
25 1099-1110 Species denotes respiratory Tax:12814
26 695-704 Species denotes SARS-CoV2 Tax:2697049
27 49-58 Disease denotes infection MESH:D007239
28 106-114 Disease denotes COVID-19 MESH:C000657245
29 457-465 Disease denotes COVID-19 MESH:C000657245
30 517-525 Disease denotes COVID-19 MESH:C000657245
31 651-665 Disease denotes critically ill MESH:D016638
32 1486-1522 Disease denotes impaired T cell function/dysfunction MESH:D003072
33 1548-1556 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-124 Sentence denotes Hyperactivation of the host immune system during infection by SARS-CoV-2 is the leading cause of death in COVID-19 patients.
T5 125-272 Sentence denotes It is also evident that patients who develop mild/moderate symptoms and successfully recover display functional and well-regulated immune response.
T6 273-475 Sentence denotes Whereas a delayed initial interferon response is associated with severe disease outcome and can be the tipping point towards immunopathological deterioration, often preceding death in COVID-19 patients.
T7 476-565 Sentence denotes Further, adaptive immune response during COVID-19 is heterogeneous and poorly understood.
T8 566-725 Sentence denotes At the same time, some studies suggest activated T and B cell response in severe and critically ill patients and the presence of SARS-CoV2-specific antibodies.
T9 726-904 Sentence denotes Thus, understanding this problem and the underlying molecular pathways implicated in host immune function/dysfunction is imperative to devise effective therapeutic interventions.
T10 905-1057 Sentence denotes In this comprehensive review, we discuss the emerging immunopathological determinants and the mechanism of virus evasion by the host cell immune system.
T11 1058-1316 Sentence denotes Using the knowledge gained from previous respiratory viruses and the emerging clinical and molecular findings on SARS-CoV-2, we have tried to provide a holistic understanding of the host innate and adaptive immune response that may determine disease outcome.
T12 1317-1557 Sentence denotes Considering the critical role of the adaptive immune system during the viral clearance, we have presented the molecular insights of the plausible mechanisms involved in impaired T cell function/dysfunction during various stages of COVID-19.