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PMC:7736111 / 85387-86943 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2130 87-90 Gene denotes CD4 Gene:920
2131 96-99 Gene denotes CD8 Gene:925
2132 305-308 Gene denotes CD4 Gene:920
2133 363-368 Gene denotes IFN-γ Gene:3458
2134 370-374 Gene denotes IL-2 Gene:3558
2135 383-387 Gene denotes IL-6 Gene:3569
2136 393-399 Gene denotes GM-CSF Gene:1437
2137 419-422 Gene denotes CD8 Gene:925
2138 502-507 Gene denotes IFN-γ Gene:3458
2139 595-615 Gene denotes granzyme A, B, and K Gene:3001
2140 624-629 Gene denotes GZM-A Gene:3001
2141 821-825 Gene denotes Tim3 Gene:84868
2142 831-836 Gene denotes NKG2A Gene:3821
2143 1349-1353 Gene denotes IL4R Gene:3566
2144 1355-1363 Gene denotes TNFSF13B Gene:10673
2145 1369-1373 Gene denotes XBP1 Gene:7494
2146 548-551 Gene denotes CD8 Gene:925
2147 36-56 Disease denotes SARS-CoV-2 infection MESH:C000657245
2148 215-224 Disease denotes infection MESH:D007239
2149 516-536 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T503 153-290 Sentence denotes These activated T cells are further recruited at the sites of infection (initially lungs) in the presence of their respective chemokines.
T504 291-508 Sentence denotes The activated CD4+ T cells are marked by the presence of cytokines like IFN-γ, IL-2, IL-12, IL-6, and GM-CSF, whereas activated CD8+T (cytotoxic T cells) are marked by the secretion of granzymes, perforins, and IFN-γ.
T505 509-837 Sentence denotes During SARS-CoV-2 infection, activated CD8+T cells exhibiting increased expression of granzyme A, B, and K (GZM-B, GZM-A, and GZM-K) were found in the lungs (Liao et al., 2020; Song et al., 2020; Zheng M. et al., 2020). (B) T cells were also found to exhibit exhausted state as marked by the expression of PD-1, Tim3, and NKG2A.
T506 838-1104 Sentence denotes However, most studies showing exhausted T cells were confined to the peripheral blood, while lungs were mostly shown to have activated T cells but with concomitant expression of some exhaustive markers, suggesting that the activation state is followed by exhaustion.
T507 1105-1477 Sentence denotes The exhaustive T cells are marked by the reduced expression of respective chemokines and cytolytic granules. (C) Similarly, antibody-producing B cells (plasmablasts; PB) were shown to exhibit activation status as reflected by the expression of IL4R, TNFSF13B, and XBP1, while at the same time, the exhausted status of these cells was also reported in the peripheral blood.
T508 1478-1556 Sentence denotes Exhaustive state of B cells is reflected by a decrease in antibody production.