PMC:7736111 / 76955-77587 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	hp_id
T18	599-614	Phenotype	denotes	Lymphocytopenia	http://purl.obolibrary.org/obo/HP_0001888

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1919	178-183	Gene	denotes	IFN-γ	Gene:3458
1920	185-189	Gene	denotes	IL-2	Gene:3558
1921	195-200	Gene	denotes	TNF-α	Gene:7124
1922	204-207	Gene	denotes	CD4	Gene:920
1923	269-273	Gene	denotes	IL-2	Gene:3558
1924	275-278	Gene	denotes	CD8	Gene:925
1925	284-289	Gene	denotes	IFN-γ	Gene:3458
1926	291-294	Gene	denotes	CD8	Gene:925
1927	442-445	Gene	denotes	CD4	Gene:920
1928	451-454	Gene	denotes	CD8	Gene:925
1929	97-105	Disease	denotes	COVID-19	MESH:C000657245
1930	599-614	Disease	denotes	Lymphocytopenia	MESH:D008231
1931	622-630	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
T451	0-112	Sentence	denotes	On the contrary, there are studies which show decreased cytokine expression by T cells in severe COVID-19 cases.
T452	113-243	Sentence	denotes	A study by Zheng H.Y. et al. (2020) showed a lower expression of IFN-γ, IL-2, and TNF-α in CD4+ T cells derived from severe cases.
T453	244-340	Sentence	denotes	Similarly, a decrease in IL-2+ CD8+ and IFN-γ+ CD8+ cells was also observed (Diao et al., 2020).
T454	341-632	Sentence	denotes	Although most studies point toward the robust activation and release of proinflammatory cytokines by CD4+ and CD8+ T cells, the discrepancy in latter studies could attribute to the functional exhaustion of these cells, which will we will discuss in section “Lymphocytopenia During COVID-19.”