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PMC:7736111 / 6849-8478 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
134 222-226 Gene denotes ACE2 Gene:59272
135 379-383 Gene denotes ACE2 Gene:59272
136 466-470 Gene denotes ACE2 Gene:59272
137 545-552 Gene denotes TMPRSS2 Gene:7113
138 554-561 Gene denotes TMPRSS2 Gene:7113
139 1325-1329 Gene denotes ACE2 Gene:59272
140 1015-1020 Gene denotes furin Gene:5045
141 18-28 Species denotes SARS-CoV-2 Tax:2697049
142 89-97 Species denotes SARS-CoV Tax:694009
143 121-131 Species denotes SARS-CoV-2 Tax:2697049
144 193-203 Species denotes SARS-CoV-2 Tax:2697049
145 946-956 Species denotes SARS-CoV-2 Tax:2697049
146 1071-1081 Species denotes SARS-CoV-2 Tax:2697049
147 1155-1164 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T40 56-309 Sentence denotes Based on available literature on SARS-CoV and recent findings on SARS-CoV-2, we suggest two different mechanisms that can be employed by SARS-CoV-2 to enter into the ACE2 expressing cells. (1) Initially the virus may use the cell membrane mode of entry.
T41 310-553 Sentence denotes The first step is the binding of the spike protein of the virus with ACE2 receptors expressed on the plasma membrane of host cells. (2) The attachment with ACE2 is followed by the cleavage of S protein by membrane bound proteases like TMPRSS2.
T42 554-1136 Sentence denotes TMPRSS2 cleaves the membrane bound virus at both S1/S2 boundary as well as at S2’ site. (3) This activates the fusion machinery, and subsequently, the viral membrane fuses with the host cell plasma membrane. (4) This leads to release of the viral nucleocapsid into the cytoplasm. (5) The replication, assembly, and maturation of virus takes places in the cytoplasm. (6) Before dissemination, SARS-CoV-2 may also undergo pre-activation in the golgi apparatus by furin proteases. (7) The fully mature and pre-activated SARS-CoV-2 eventually disseminates from host cells by exocytosis.
T43 1137-1266 Sentence denotes During subsequent infection cycles, the virus may utilize either cell membrane or (8–11) the more probable endocytic entry route.
T44 1267-1629 Sentence denotes In the endocytic mode of entry, (8) after attachment with ACE2, (9) the virus gets endocytosed and (10) then processed at the S2’ region by endosomal proteases like cathepsins, to activate membrane fusion. (11) Finally, the viral components are released into the cytoplasm by fusion of the viral membranes with endosomal membrane, leading to repeat of the cycle.