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PMC:7736111 / 6839-8478 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
134 232-236 Gene denotes ACE2 Gene:59272
135 389-393 Gene denotes ACE2 Gene:59272
136 476-480 Gene denotes ACE2 Gene:59272
137 555-562 Gene denotes TMPRSS2 Gene:7113
138 564-571 Gene denotes TMPRSS2 Gene:7113
139 1335-1339 Gene denotes ACE2 Gene:59272
140 1025-1030 Gene denotes furin Gene:5045
141 28-38 Species denotes SARS-CoV-2 Tax:2697049
142 99-107 Species denotes SARS-CoV Tax:694009
143 131-141 Species denotes SARS-CoV-2 Tax:2697049
144 203-213 Species denotes SARS-CoV-2 Tax:2697049
145 956-966 Species denotes SARS-CoV-2 Tax:2697049
146 1081-1091 Species denotes SARS-CoV-2 Tax:2697049
147 1165-1174 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T39 0-65 Sentence denotes FIGURE 1 Proposed model of SARS-CoV-2 entry into the host cells.
T40 66-319 Sentence denotes Based on available literature on SARS-CoV and recent findings on SARS-CoV-2, we suggest two different mechanisms that can be employed by SARS-CoV-2 to enter into the ACE2 expressing cells. (1) Initially the virus may use the cell membrane mode of entry.
T41 320-563 Sentence denotes The first step is the binding of the spike protein of the virus with ACE2 receptors expressed on the plasma membrane of host cells. (2) The attachment with ACE2 is followed by the cleavage of S protein by membrane bound proteases like TMPRSS2.
T42 564-1146 Sentence denotes TMPRSS2 cleaves the membrane bound virus at both S1/S2 boundary as well as at S2’ site. (3) This activates the fusion machinery, and subsequently, the viral membrane fuses with the host cell plasma membrane. (4) This leads to release of the viral nucleocapsid into the cytoplasm. (5) The replication, assembly, and maturation of virus takes places in the cytoplasm. (6) Before dissemination, SARS-CoV-2 may also undergo pre-activation in the golgi apparatus by furin proteases. (7) The fully mature and pre-activated SARS-CoV-2 eventually disseminates from host cells by exocytosis.
T43 1147-1276 Sentence denotes During subsequent infection cycles, the virus may utilize either cell membrane or (8–11) the more probable endocytic entry route.
T44 1277-1639 Sentence denotes In the endocytic mode of entry, (8) after attachment with ACE2, (9) the virus gets endocytosed and (10) then processed at the S2’ region by endosomal proteases like cathepsins, to activate membrane fusion. (11) Finally, the viral components are released into the cytoplasm by fusion of the viral membranes with endosomal membrane, leading to repeat of the cycle.