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PMC:7736111 / 64283-65313 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1683 103-106 Gene denotes CD4 Gene:920
1684 361-364 Gene denotes CD4 Gene:920
1685 502-505 Gene denotes CD4 Gene:920
1686 520-523 Gene denotes CD8 Gene:925
1687 731-735 Gene denotes ORF8 Gene:43740577
1688 796-801 Gene denotes ORF3a Gene:43740569
1689 36-44 Species denotes patients Tax:9606
1690 168-176 Species denotes patients Tax:9606
1691 275-285 Species denotes SARS-CoV-2 Tax:2697049
1692 482-492 Species denotes SARS-CoV-2 Tax:2697049
1693 555-563 Species denotes patients Tax:9606
1694 909-919 Species denotes SARS-CoV-2 Tax:2697049
1695 931-939 Species denotes patients Tax:9606
1696 27-35 Disease denotes COVID-19 MESH:C000657245
1697 159-167 Disease denotes COVID-19 MESH:C000657245
1698 418-440 Disease denotes coronavirus infections MESH:D018352
1699 1013-1029 Disease denotes viral infections MESH:D001102

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T375 0-177 Sentence denotes By studying a cohort of 18 COVID-19 patients and 64 healthy donors, Braun et al. (2020) found reactive CD4+ (83%) cells in blood-derived from the convalescing COVID-19 patients.
T376 178-247 Sentence denotes These reactive T cells were found specifically against the S protein.
T377 248-441 Sentence denotes Interestingly about 35% of SARS-CoV-2 seronegative healthy donors also showed the presence of S protein reactive CD4+ T cells indicating previous exposure to the related coronavirus infections.
T378 442-596 Sentence denotes Simultaneously, another study has found SARS-CoV-2 specific CD4+ T (100%) and CD8+ T (70%) cells in convalescent patients (n = 20) (Grifoni et al., 2020).
T379 597-802 Sentence denotes In addition to being majorly reactive against S protein, the study found additional targets of these T cells in the form of M, N, and ORF8 proteins and other non-structural proteins like NSP3, NSP4, ORF3a.
T380 803-1030 Sentence denotes Further, in line with the study by Braun et al. (2020), T cells were found reactive against 40–60% of the SARS-CoV-2 uninfected patients, suggesting the presence of these reactive cells in response to previous viral infections.