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PMC:7736111 / 60582-62566 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1608 483-486 Gene denotes CD4 Gene:920
1609 566-571 Gene denotes CXCR5 Gene:643
1610 576-581 Gene denotes IL-21 Gene:59067
1611 606-610 Gene denotes CCR7 Gene:1236
1612 612-617 Gene denotes IFN-γ Gene:3458
1613 619-623 Gene denotes IL-4 Gene:3565
1614 629-634 Gene denotes IL-17 Gene:3605
1615 758-763 Gene denotes CD40L Gene:959
1616 907-912 Gene denotes CD40L Gene:959
1617 953-958 Gene denotes IL-21 Gene:59067
1618 1036-1040 Gene denotes IL-6 Gene:3569
1619 1045-1050 Gene denotes IL-27 Gene:246778
1620 87-103 Disease denotes viral infections MESH:D001102
1621 386-394 Disease denotes COVID-19 MESH:C000657245
1622 1250-1268 Disease denotes SARS-CoV infection MESH:C000657245
1623 1680-1692 Disease denotes cytotoxicity MESH:D064420

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T352 0-15 Sentence denotes B Cell Response
T353 16-104 Sentence denotes B cells, along with T cells, form the central adaptive response during viral infections.
T354 105-235 Sentence denotes B cell response is highly specific, mounted by the virus-specific antibodies and other effector cytokines secreted by these cells.
T355 236-417 Sentence denotes B cell activation can be follicular helper T (TFH) cell-dependent, or in some instances, independent of helper cells; both instances are prevalent in COVID-19 (Mathew et al., 2020).
T356 418-701 Sentence denotes Under the influence of antigen-presenting dendritic cells, naïve CD4+ T cells differentiate into TFH cells, which are marked by high expressions of CXCR5 and IL-21, and low expressions of CCR7, IFN-γ, IL-4, and IL-17 (Rasheed et al., 2006; Nurieva et al., 2008; Morita et al., 2011).
T357 702-895 Sentence denotes The activated TFH cells interact with B cells via CD40R-CD40L and other associated receptors to induce the production of antigen-specific antibodies in a well-coordinated and regulated process.
T358 896-1124 Sentence denotes This CD40R-CD40L interaction along with the secretion of IL-21 also allows the formation of long-lived memory B cells, while B cell-derived IL-6 and IL-27 help in reciprocal maintenance of TFH cells (Nurieva et al., 2008, 2009).
T359 1125-1289 Sentence denotes A previous animal study has shown the essential role of these helper cells in mounting an adequate antibody response against SARS-CoV infection (Chen et al., 2010).
T360 1290-1398 Sentence denotes The depletion of these cells was associated with a decline in antibody response and reduced viral clearance.
T361 1399-1517 Sentence denotes Thus, virus-specific antibodies produced by B cells are critical for an effective immune response mounted by the host.
T362 1518-1722 Sentence denotes These antibodies facilitate the clearance of the virus by either directly activating phagocytosis, opsonization, or activation of the antibody-dependent cellular cytotoxicity (ADCC) via effector NK cells.
T363 1723-1834 Sentence denotes Cytokines released by the activation of innate and adaptive immune systems also activate the complement system.
T364 1835-1984 Sentence denotes Viruses coated with the secreted antibodies from plasma cells eventually get eliminated by the complement system, reviewed by Risitano et al. (2020).