PMC:7736111 / 58204-59139 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	hp_id
T14	218-242	Phenotype	denotes	interstitial pneumonitis	http://purl.obolibrary.org/obo/HP_0006515

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1539	64-67	Gene	denotes	CD4	Gene:920
1540	159-162	Gene	denotes	CD4	Gene:920
1541	809-812	Gene	denotes	CD4	Gene:920
1542	820-823	Gene	denotes	CD8	Gene:925
1543	489-492	Gene	denotes	CD4	Gene:920
1544	498-501	Gene	denotes	CD8	Gene:925
1545	346-349	Gene	denotes	CD8	Gene:925
1546	337-340	Gene	denotes	CD4	Gene:920
1547	78-86	Species	denotes	SARS-CoV	Tax:694009
1548	528-536	Species	denotes	patients	Tax:9606
1549	231-242	Disease	denotes	pneumonitis	MESH:D011014
1550	660-678	Disease	denotes	SARS-CoV infection	MESH:C000657245
1551	879-897	Disease	denotes	SARS-CoV infection	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
T336	0-141	Sentence	denotes	Animal studies have revealed the critical molecular insights of CD4+ cells in SARS-CoV clearance and attenuation of a pathological condition.
T337	142-281	Sentence	denotes	The depletion of CD4+ cells was associated with reduced virus clearance and interstitial pneumonitis (Jin et al., 2005; Wang et al., 2006).
T338	282-407	Sentence	denotes	In comparison, the adoptive transfer of virus-specific CD4+ and CD8+ T cells resulted in viral clearance (Zhao et al., 2010).
T339	408-624	Sentence	denotes	Similarly, clinical data has consistently shown the presence of antigen-specific CD4+ and CD8+ T cells in the recovered patients, akin to what was found in immunized animals, reviewed in Channappanavar et al. (2014).
T340	625-761	Sentence	denotes	On the other hand, severe cases of SARS-CoV infection were associated with a decline in T cells, as will be discussed in later sections.
T341	762-935	Sentence	denotes	Thus, based on these animal and clinical data, CD4+ T and CD8+ T cells were central to the antiviral response during SARS-CoV infection (Peng et al., 2006; Oh et al., 2012).