Id |
Subject |
Object |
Predicate |
Lexical cue |
T318 |
0-213 |
Sentence |
denotes |
Generation of early adaptive immune response is critical for the selective elimination of virus-infected cells and neutralization of viral antigens, thereby preventing the damage to the underlying lung parenchyma. |
T319 |
214-419 |
Sentence |
denotes |
Cytokines, chemokines, PAMPs, and DAMPs released by infected ATII and activated AMs in the lung are adequate to mount a well-coordinated and regulated adaptive immune response by priming lung resident DCs. |
T320 |
420-538 |
Sentence |
denotes |
After encountering the antigen-presenting DCs, naive CD4+ T cells differentiate into effector and memory CD4+ T cells. |
T321 |
539-761 |
Sentence |
denotes |
At least five different CD4+ T cell lineages are known (TH1, TH2, TH17, TFH, and TREG cells) with prominent roles of TH1 and TFH cells in mounting antiviral response during SARS-CoV infection (Channappanavar et al., 2014). |
T322 |
762-871 |
Sentence |
denotes |
Additionally, some studies have also shown a functional TH2 response in PBMCs derived from COVID-19 patients. |
T323 |
872-1005 |
Sentence |
denotes |
Release of TH2 specific cytokines like IL-4 and IL-5 was observed in vitro after these cells were stimulated (Weiskopf et al., 2020). |
T324 |
1006-1153 |
Sentence |
denotes |
Similarly, these patients show enhanced production of IL-17 along with other TH17 cell-specific cytokines (Liu J. et al., 2020; Wu and Yang, 2020). |
T325 |
1154-1360 |
Sentence |
denotes |
These findings suggest that the TH cell response in COVID-19 patients is complex concerning other infections, and this complexity may partly depend upon the prevailing pathophysiological state of a patient. |