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PMC:7736111 / 55017-56377 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1437 473-476 Gene denotes CD4 Gene:920
1438 525-528 Gene denotes CD4 Gene:920
1439 563-566 Gene denotes CD4 Gene:920
1440 595-598 Gene denotes TH1 Gene:51497
1441 911-915 Gene denotes IL-4 Gene:3565
1442 920-924 Gene denotes IL-5 Gene:3567
1443 1060-1065 Gene denotes IL-17 Gene:3605
1444 656-659 Gene denotes TH1 Gene:51497
1445 862-870 Species denotes patients Tax:9606
1446 1023-1031 Species denotes patients Tax:9606
1447 1215-1223 Species denotes patients Tax:9606
1448 1352-1359 Species denotes patient Tax:9606
1449 818-821 Chemical denotes TH2
1450 90-104 Disease denotes virus-infected MESH:D001102
1451 266-274 Disease denotes infected MESH:D007239
1452 712-730 Disease denotes SARS-CoV infection MESH:C000657245
1453 853-861 Disease denotes COVID-19 MESH:C000657245
1454 1206-1214 Disease denotes COVID-19 MESH:C000657245
1455 1252-1262 Disease denotes infections MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T318 0-213 Sentence denotes Generation of early adaptive immune response is critical for the selective elimination of virus-infected cells and neutralization of viral antigens, thereby preventing the damage to the underlying lung parenchyma.
T319 214-419 Sentence denotes Cytokines, chemokines, PAMPs, and DAMPs released by infected ATII and activated AMs in the lung are adequate to mount a well-coordinated and regulated adaptive immune response by priming lung resident DCs.
T320 420-538 Sentence denotes After encountering the antigen-presenting DCs, naive CD4+ T cells differentiate into effector and memory CD4+ T cells.
T321 539-761 Sentence denotes At least five different CD4+ T cell lineages are known (TH1, TH2, TH17, TFH, and TREG cells) with prominent roles of TH1 and TFH cells in mounting antiviral response during SARS-CoV infection (Channappanavar et al., 2014).
T322 762-871 Sentence denotes Additionally, some studies have also shown a functional TH2 response in PBMCs derived from COVID-19 patients.
T323 872-1005 Sentence denotes Release of TH2 specific cytokines like IL-4 and IL-5 was observed in vitro after these cells were stimulated (Weiskopf et al., 2020).
T324 1006-1153 Sentence denotes Similarly, these patients show enhanced production of IL-17 along with other TH17 cell-specific cytokines (Liu J. et al., 2020; Wu and Yang, 2020).
T325 1154-1360 Sentence denotes These findings suggest that the TH cell response in COVID-19 patients is complex concerning other infections, and this complexity may partly depend upon the prevailing pathophysiological state of a patient.