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PMC:7736111 / 5415-6838 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
107 140-144 Gene denotes ACE2 Gene:59272
108 235-242 Gene denotes TMPRSS2 Gene:7113
109 299-304 Gene denotes furin Gene:5045
110 1240-1244 Gene denotes ACE2 Gene:59272
111 170-171 Gene denotes S Gene:43740568
112 0-10 Species denotes SARS-CoV-2 Tax:2697049
113 33-41 Species denotes SARS-CoV Tax:694009
114 327-337 Species denotes SARS-CoV-2 Tax:2697049
115 697-705 Species denotes SARS-CoV Tax:694009
116 827-837 Species denotes SARS-CoV-2 Tax:2697049
117 1331-1341 Species denotes SARS-CoV-2 Tax:2697049
118 1349-1357 Species denotes SARS-CoV Tax:694009
119 811-819 Disease denotes infected MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T33 0-155 Sentence denotes SARS-CoV-2, like its predecessor SARS-CoV, employs spike (S) protein to enter into the eukaryotic cells by binding to the surface-expressed ACE2 receptors.
T34 156-483 Sentence denotes Upon binding, S protein priming takes place by the membrane expressed protease TMPRSS2 or endosomal proteases such as cathepsin, elastase, and furin (which is specific to SARS-CoV-2) to induce fusion between the viral and host cell membrane (Hoffmann et al., 2020; Shang et al., 2020; Walls et al., 2020; Wang Q. et al., 2020).
T35 484-761 Sentence denotes Following these well-coordinated events, viral genetic material will release in a biphasic manner, i.e. either by direct fusion with the plasma membrane or by following the endocytic route as shown previously for SARS-CoV (Belouzard et al., 2012; Shang et al., 2020; Figure 1).
T36 762-1180 Sentence denotes An increasing list of cell types appear directly infected by the SARS-CoV-2, which include the alveolar epithelial type II cell (ATII) as the principal targets, and other cell types lining various tissues such as bronchial epithelial cells in lungs, goblet cells in the nasal cavity, macrophages, esophageal cells, pancreatic β-cells, and gastrointestinal epithelial cells (Li M.Y. et al., 2020; Sungnak et al., 2020).
T37 1181-1275 Sentence denotes All these cell types express the S protein target receptor ACE2, albeit with lower expression.
T38 1276-1423 Sentence denotes However, ATII cells remain the predominant targets for SARS-CoV-2 as for SARS-CoV, which are involved in the sensing of the various viral proteins.