| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T296 |
0-202 |
Sentence |
denotes |
Natural killer cells are essential in the early phase of viral infection to assist in the clearance of the virus by interacting with death receptors expressed on the infected cells (Vidal et al., 2011). |
| T297 |
203-350 |
Sentence |
denotes |
Previous clinical studies have shown decreased NK cell number in SARS-CoV patients, which was more pronounced in severe cases (Wang and Xia, 2004). |
| T298 |
351-593 |
Sentence |
denotes |
A recent blood profile of COVID-19 patients suggested a similar decline in the number of NK cells in severe cases, along with an increased expression of exhaustion markers (Chen X. et al., 2020; Tan L. et al., 2020b; Zheng H.Y. et al., 2020). |
| T299 |
594-740 |
Sentence |
denotes |
On the contrary, no significant difference was found in the number of total NK cells, in non-ICU vs 10 ICU admitted patients (Zhou et al., 2020a). |
| T300 |
741-897 |
Sentence |
denotes |
This discrepancy in number could probably be due to differential temporal immune response and the underlying prevailing disease conditions in some patients. |
| T301 |
898-1126 |
Sentence |
denotes |
Immune cell profiling data from early recovery stage (ERS) and late recovery stage (LRS) COVID-19 patients revealed a biphasic effect, with fewer NK cells during early recovery ERS, which recovered during LRS (Wen et al., 2020). |
| T302 |
1127-1299 |
Sentence |
denotes |
Thus, besides the underlying disease state, the NK cell number may also be sensitive to the time of sample collection and hence may not serve as a potential disease marker. |
| T303 |
1300-1590 |
Sentence |
denotes |
Further, these studies could also suffer from the limitation of the variation in the age of the patients studied which may make it difficult to provide a definite role of these cells concerning COVID-19 disease severity (Nikolich-Zugich et al., 2020), necessitating more conclusive studies. |
