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PMC:7736111 / 49599-51041 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1317 479-484 Gene denotes TNF-α Gene:7124
1318 486-490 Gene denotes IL-6 Gene:3569
1319 492-497 Gene denotes IL-1β Gene:3552
1320 499-503 Gene denotes IL-7 Gene:3574
1321 505-510 Gene denotes IL-23 Gene:51561
1322 719-727 Gene denotes CCL2/3/4 Gene:6347
1323 729-737 Gene denotes CXCL1-13 Gene:2919
1324 110-119 Disease denotes infection MESH:D007239
1325 336-345 Disease denotes infection MESH:D007239
1329 1230-1238 Species denotes patients Tax:9606
1330 907-915 Disease denotes COVID-19 MESH:C000657245
1331 1221-1229 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T286 0-27 Sentence denotes Proinflammatory neutrophils
T287 28-257 Sentence denotes Like other innate immune cells, neutrophils are protective in the early phases of infection by neutralizing the viral particles and release of protective molecules to interfere with the viral propagation (Drescher and Bai, 2013).
T288 258-395 Sentence denotes However, in severe cases, the number of these cells increases at the sites of infection and they become the leading damage-causing cells.
T289 396-646 Sentence denotes Excessive infiltration of these cells in the lungs is associated with secretion of TNF-α, IL-6, IL-1β, IL-7, IL-23, and IL-36, along with a broad range of other cytokines and damage-causing neutrophil extracellular traps (NETs; Tecchio et al., 2014).
T290 647-826 Sentence denotes Additionally, these neutrophils also secrete a range of chemokines like CCL2/3/4, CXCL1-13 to attract more neutrophils and monocytes from the circulation (Sokol and Luster, 2015).
T291 827-916 Sentence denotes Emerging evidence suggests a pivotal role of neutrophils in the pathogenesis of COVID-19.
T292 917-1131 Sentence denotes Immune cell profiling revealed activated status of these cells which was associated with increased levels of NETs and correlated with acute-phase reaction (Chen G. et al., 2020; Qin et al., 2020; Zuo et al., 2020).
T293 1132-1279 Sentence denotes Similarly, an increase in the number of activated neutrophils was present in the BALF of COVID-19 patients (Liao et al., 2020; Xiong et al., 2020).
T294 1280-1442 Sentence denotes Thus, based on these recently published studies, the neutrophil number in the blood can be used as a predictive marker for disease severity (Zhang et al., 2020a).