PMC:7736111 / 37881-38565 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Based on previous molecular and clinical studies on SARS-CoV and the recent data on SARS-CoV-2, it is becoming evident that the delay in primary IFN response may be due to multiple factors such as (1) poor overall immune function of a patient with a compromised adaptive response as in older people, (2) patients with comorbidity, (3) genetic factors or epigenetic changes associated with crucial genes and transcriptional factors involved in IFN signaling, and (4) age and sex of the patient, probably making the older individuals and males more susceptible to COVID-19 (Bastard et al., 2020; Li M.Y. et al., 2020; Nguyen et al., 2020; Verdecchia et al., 2020; Zhou F. et al., 2020).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"958","span":{"begin":145,"end":148},"obj":"Gene"},{"id":"959","span":{"begin":443,"end":446},"obj":"Gene"},{"id":"961","span":{"begin":52,"end":60},"obj":"Species"},{"id":"962","span":{"begin":84,"end":94},"obj":"Species"},{"id":"963","span":{"begin":235,"end":242},"obj":"Species"},{"id":"964","span":{"begin":292,"end":298},"obj":"Species"},{"id":"965","span":{"begin":304,"end":312},"obj":"Species"},{"id":"966","span":{"begin":485,"end":492},"obj":"Species"},{"id":"967","span":{"begin":562,"end":570},"obj":"Disease"}],"attributes":[{"id":"A958","pred":"tao:has_database_id","subj":"958","obj":"Gene:3439"},{"id":"A959","pred":"tao:has_database_id","subj":"959","obj":"Gene:3439"},{"id":"A961","pred":"tao:has_database_id","subj":"961","obj":"Tax:694009"},{"id":"A962","pred":"tao:has_database_id","subj":"962","obj":"Tax:2697049"},{"id":"A963","pred":"tao:has_database_id","subj":"963","obj":"Tax:9606"},{"id":"A964","pred":"tao:has_database_id","subj":"964","obj":"Tax:9606"},{"id":"A965","pred":"tao:has_database_id","subj":"965","obj":"Tax:9606"},{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Tax:9606"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"MESH:C000657245"},{"subj":"958","pred":"source","obj":"LitCovid-PubTator"},{"subj":"959","pred":"source","obj":"LitCovid-PubTator"},{"subj":"961","pred":"source","obj":"LitCovid-PubTator"},{"subj":"962","pred":"source","obj":"LitCovid-PubTator"},{"subj":"963","pred":"source","obj":"LitCovid-PubTator"},{"subj":"964","pred":"source","obj":"LitCovid-PubTator"},{"subj":"965","pred":"source","obj":"LitCovid-PubTator"},{"subj":"966","pred":"source","obj":"LitCovid-PubTator"},{"subj":"967","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T218","span":{"begin":0,"end":684},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T218","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecd693","default":true},{"id":"LitCovid-sentences","color":"#bc93ec"}]}]}}