PMC:7736111 / 34069-34675 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T10","span":{"begin":331,"end":340},"obj":"Phenotype"}],"attributes":[{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"Lung resident macrophages like AM are generally present in the terminal airways where they serve a regulatory function to maintain normal cellular homeostasis. Previous studies have defined a critical role of these cells in successful viral clearance (Hartwig et al., 2014). Depletion of these cells in animals infected with mouse hepatitis virus type 1 (MHV-1) resulted in a marked reduction of antiviral response. AMs have also been shown indispensable during SARS-CoV infection. The depletion of these cells was associated with worsened disease outcomes in a mouse model of SARS-CoV (Page et al., 2012)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"896","span":{"begin":325,"end":346},"obj":"Species"},{"id":"897","span":{"begin":355,"end":360},"obj":"Species"},{"id":"898","span":{"begin":562,"end":567},"obj":"Species"},{"id":"899","span":{"begin":577,"end":585},"obj":"Species"},{"id":"900","span":{"begin":311,"end":319},"obj":"Disease"},{"id":"901","span":{"begin":462,"end":480},"obj":"Disease"}],"attributes":[{"id":"A896","pred":"tao:has_database_id","subj":"896","obj":"Tax:11138"},{"id":"A897","pred":"tao:has_database_id","subj":"897","obj":"Tax:137443"},{"id":"A898","pred":"tao:has_database_id","subj":"898","obj":"Tax:10090"},{"id":"A899","pred":"tao:has_database_id","subj":"899","obj":"Tax:694009"},{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"MESH:D007239"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Lung resident macrophages like AM are generally present in the terminal airways where they serve a regulatory function to maintain normal cellular homeostasis. Previous studies have defined a critical role of these cells in successful viral clearance (Hartwig et al., 2014). Depletion of these cells in animals infected with mouse hepatitis virus type 1 (MHV-1) resulted in a marked reduction of antiviral response. AMs have also been shown indispensable during SARS-CoV infection. The depletion of these cells was associated with worsened disease outcomes in a mouse model of SARS-CoV (Page et al., 2012)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T196","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T197","span":{"begin":160,"end":274},"obj":"Sentence"},{"id":"T198","span":{"begin":275,"end":415},"obj":"Sentence"},{"id":"T199","span":{"begin":416,"end":481},"obj":"Sentence"},{"id":"T200","span":{"begin":482,"end":606},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Lung resident macrophages like AM are generally present in the terminal airways where they serve a regulatory function to maintain normal cellular homeostasis. Previous studies have defined a critical role of these cells in successful viral clearance (Hartwig et al., 2014). Depletion of these cells in animals infected with mouse hepatitis virus type 1 (MHV-1) resulted in a marked reduction of antiviral response. AMs have also been shown indispensable during SARS-CoV infection. The depletion of these cells was associated with worsened disease outcomes in a mouse model of SARS-CoV (Page et al., 2012)."}