PMC:7736111 / 27391-28122 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"698","span":{"begin":293,"end":298},"obj":"Gene"},{"id":"699","span":{"begin":571,"end":576},"obj":"Gene"},{"id":"700","span":{"begin":308,"end":312},"obj":"Species"},{"id":"701","span":{"begin":327,"end":335},"obj":"Species"},{"id":"702","span":{"begin":537,"end":545},"obj":"Species"},{"id":"703","span":{"begin":610,"end":614},"obj":"Species"},{"id":"704","span":{"begin":273,"end":291},"obj":"Disease"},{"id":"705","span":{"begin":313,"end":321},"obj":"Disease"}],"attributes":[{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"Gene:20846"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"Gene:3454"},{"id":"A700","pred":"tao:has_database_id","subj":"700","obj":"Tax:10090"},{"id":"A701","pred":"tao:has_database_id","subj":"701","obj":"Tax:694009"},{"id":"A702","pred":"tao:has_database_id","subj":"702","obj":"Tax:694009"},{"id":"A703","pred":"tao:has_database_id","subj":"703","obj":"Tax:10090"},{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:C000657245"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"By initiating an early antiviral response, signaling via IFNs and ISGs is critical for the viral clearance and an impediment for the development of the pathological state. Several in vitro and animal studies have established the central role of these signaling pathways in SARS-CoV infection. STAT1 knockout mice infected with SARS-CoV exhibited severe disease symptoms, conferred by increased viral replication and propagation and was further associated with reduced survival rate (Hogan et al., 2004; Frieman et al., 2010). Similarly, SARS-CoV propagation increases in IFNR1-/- and ILFNLR1/- double knockout mice, suggesting an essential role of these signaling pathways in mitigating antiviral response (Mahlakõiv et al., 2012)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T159","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T160","span":{"begin":172,"end":292},"obj":"Sentence"},{"id":"T161","span":{"begin":293,"end":525},"obj":"Sentence"},{"id":"T162","span":{"begin":526,"end":731},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"By initiating an early antiviral response, signaling via IFNs and ISGs is critical for the viral clearance and an impediment for the development of the pathological state. Several in vitro and animal studies have established the central role of these signaling pathways in SARS-CoV infection. STAT1 knockout mice infected with SARS-CoV exhibited severe disease symptoms, conferred by increased viral replication and propagation and was further associated with reduced survival rate (Hogan et al., 2004; Frieman et al., 2010). Similarly, SARS-CoV propagation increases in IFNR1-/- and ILFNLR1/- double knockout mice, suggesting an essential role of these signaling pathways in mitigating antiviral response (Mahlakõiv et al., 2012)."}