PMC:7736111 / 26425-27369 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"686","span":{"begin":353,"end":357},"obj":"Species"},{"id":"687","span":{"begin":575,"end":583},"obj":"Species"},{"id":"688","span":{"begin":566,"end":574},"obj":"Disease"},{"id":"689","span":{"begin":707,"end":715},"obj":"Disease"}],"attributes":[{"id":"A686","pred":"tao:has_database_id","subj":"686","obj":"Tax:11118"},{"id":"A687","pred":"tao:has_database_id","subj":"687","obj":"Tax:9606"},{"id":"A688","pred":"tao:has_database_id","subj":"688","obj":"MESH:C000657245"},{"id":"A689","pred":"tao:has_database_id","subj":"689","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A balance between successful evasion of the virus from host cell sensing pathways and the counter mechanisms developed by the host cells to overcome these inhibitory effects determines whether an early immune response could be generated or not (Liang et al., 2020). Though most of the studies point towards the successful evasion mechanisms employed by CoVs, emerging evidence suggests that an adequate early antiviral response could be mounted (Park and Iwasaki, 2020). That early response may hold the key for limiting the viral propagation in the majority of the COVID-19 patients (approx 80%) who are asymptomatic or develop mild symptoms and successfully clear the virus. Considered the recent work on COVID-19, here we provide a detailed molecular and clinical understanding of the innate immune response. We specifically discuss how these immune responses dictate the recovery from disease or development of the immunopathological state."}

{"project":"LitCovid-sentences","denotations":[{"id":"T153","span":{"begin":0,"end":265},"obj":"Sentence"},{"id":"T154","span":{"begin":266,"end":470},"obj":"Sentence"},{"id":"T155","span":{"begin":471,"end":676},"obj":"Sentence"},{"id":"T156","span":{"begin":677,"end":811},"obj":"Sentence"},{"id":"T157","span":{"begin":812,"end":944},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A balance between successful evasion of the virus from host cell sensing pathways and the counter mechanisms developed by the host cells to overcome these inhibitory effects determines whether an early immune response could be generated or not (Liang et al., 2020). Though most of the studies point towards the successful evasion mechanisms employed by CoVs, emerging evidence suggests that an adequate early antiviral response could be mounted (Park and Iwasaki, 2020). That early response may hold the key for limiting the viral propagation in the majority of the COVID-19 patients (approx 80%) who are asymptomatic or develop mild symptoms and successfully clear the virus. Considered the recent work on COVID-19, here we provide a detailed molecular and clinical understanding of the innate immune response. We specifically discuss how these immune responses dictate the recovery from disease or development of the immunopathological state."}