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PMC:7736111 / 1659-5311 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 28-37 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 1873-1906 Phenotype denotes impaired adaptive immune response http://purl.obolibrary.org/obo/HP_0031404
T4 2592-2612 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 2725-2750 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T6 2756-2771 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888
T7 3607-3621 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
64 2414-2418 Gene denotes IL-6 Gene:3569
65 2791-2794 Gene denotes CD4 Gene:920
66 2797-2800 Gene denotes CD8 Gene:925
67 184-194 Species denotes SARS-CoV-2 Tax:2697049
68 406-416 Species denotes SARS-CoV-2 Tax:2697049
69 493-503 Species denotes SARS-CoV-2 Tax:2697049
70 577-585 Species denotes SARS-CoV Tax:694009
71 825-838 Species denotes coronaviruses Tax:11118
72 1698-1706 Species denotes patients Tax:9606
73 2081-2089 Species denotes patients Tax:9606
74 2172-2180 Species denotes patients Tax:9606
75 2567-2575 Species denotes patients Tax:9606
76 2997-3005 Species denotes patients Tax:9606
77 3328-3336 Species denotes patients Tax:9606
78 3643-3651 Species denotes patients Tax:9606
79 1236-1247 Species denotes respiratory Tax:12814
80 28-37 Disease denotes pneumonia MESH:D011014
81 159-167 Disease denotes COVID-19 MESH:C000657245
82 1175-1184 Disease denotes infection MESH:D007239
83 1645-1654 Disease denotes infection MESH:D007239
84 2072-2080 Disease denotes COVID-19 MESH:C000657245
85 2558-2566 Disease denotes COVID-19 MESH:C000657245
86 2586-2621 Disease denotes acute respiratory distress syndrome MESH:D012128
87 2623-2627 Disease denotes ARDS MESH:D012128
88 2645-2663 Disease denotes hyper inflammation MESH:D007249
89 2756-2771 Disease denotes lymphocytopenia MESH:D008231
90 2947-2969 Disease denotes multiple organ failure MESH:D009102
91 3319-3327 Disease denotes COVID-19 MESH:C000657245
92 3626-3630 Disease denotes ARDS MESH:D012128
93 3634-3642 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T14 0-262 Sentence denotes Following reports of severe pneumonia cases of unknown etiology from Wuhan, China, multiple groups identified the pathogenic agent responsible for the current COVID-19 pandemic as the SARS-CoV-2 virus (Chan et al., 2020; Huang C. et al., 2020; Zhu et al., 2020).
T15 263-463 Sentence denotes The last several months have seen an unprecedented surge in research efforts to understand the underlying molecular mechanisms associated with SARS-CoV-2 infectivity, immunogenicity, and pathogenesis.
T16 464-737 Sentence denotes Since it is now evident that SARS-CoV-2 employs the same set of receptors and host cells, previously utilized by SARS-CoV, various disease models were developed to understand the molecular networks implicated in viral evasion, host immune response, and immuno-pathogenesis.
T17 738-919 Sentence denotes Multiple factors and pathways are already known based on previous knowledge from other coronaviruses, which have shown promising potential as therapeutic targets (Tay et al., 2020).
T18 920-1139 Sentence denotes But a more comprehensive understanding to develop highly effective therapies is yet to emerge, which demands better molecular details at various stages of the virus propagation and disease progression in the host cells.
T19 1140-1366 Sentence denotes In the initial early mild phase of infection (Stage I), the virus remains confined to the upper respiratory tract (nasal cells, some areas of pharynx and larynx) which elicits low levels of the innate immune response (if any).
T20 1367-1524 Sentence denotes This asymptomatic state lasts for a couple of days (generally one or two days) before the virus propagates to the conducting and terminal airways (Stage II).
T21 1525-1655 Sentence denotes During this stage of the disease, an optimal but controlled adaptive and innate immune response will help to combat the infection.
T22 1656-1860 Sentence denotes Successful viral clearance from recovered patients, show the presence of adequate adaptive immune cells along with the immunomodulatory molecules and neutralizing antibodies (Cao, 2020; Tay et al., 2020).
T23 1861-2114 Sentence denotes However, an impaired adaptive immune response at this stage, with concomitant overactivation of the innate immune system (inflammatory macrophages and neutrophils) can lead to severe disease symptoms in ∼20% of COVID-19 patients (Wu and McGoogan, 2020).
T24 2115-2320 Sentence denotes Recent clinical and histopathological data from deceased patients suggest adaptive immune dysfunction and heightened proinflammatory response with inflammatory cell infiltration into the lungs (Stage III).
T25 2321-2536 Sentence denotes Further, the disease severity positively correlated with increased levels of proinflammatory IL-6 and an increase in the neutrophil/lymphocyte ratio (Liu T. et al., 2020; Tan L. et al., 2020b; Tan M. et al., 2020c).
T26 2537-2838 Sentence denotes Between 3 and 17% of COVID-19 patients developed acute respiratory distress syndrome (ARDS), as a result of hyper inflammation (excessive infiltration of activated innate immune cells and cytokine release syndrome) and lymphocytopenia (reduced levels of CD4+, CD8+, and B cells) (Gibson et al., 2020).
T27 2839-3109 Sentence denotes These changes are followed by cell death and tissue destruction, which ultimately leads to airway collapse, multiple organ failure and death in 67–85% of ICU patients, based on the available data so far (Wu and McGoogan, 2020; Xu Z. et al., 2020; Zhang H. et al., 2020).
T28 3110-3273 Sentence denotes Here, we discuss the molecular determinants implicated in the success or failure of recovery through various phases of immune response generated by the host cells.
T29 3274-3551 Sentence denotes We have built an immunological trajectory of COVID-19 patients who have successfully cleared the virus against those who have developed severe symptoms, with emphasis on virus sensing and evasion mechanisms, and the spatiotemporal role of the innate and adaptive immune system.
T30 3552-3652 Sentence denotes Further, we provided cellular and molecular details of cytokine storm and ARDS in COVID-19 patients.