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PMC:7736111 / 1646-5311 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 41-50 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 1886-1919 Phenotype denotes impaired adaptive immune response http://purl.obolibrary.org/obo/HP_0031404
T4 2605-2625 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 2738-2763 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T6 2769-2784 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888
T7 3620-3634 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
64 2427-2431 Gene denotes IL-6 Gene:3569
65 2804-2807 Gene denotes CD4 Gene:920
66 2810-2813 Gene denotes CD8 Gene:925
67 197-207 Species denotes SARS-CoV-2 Tax:2697049
68 419-429 Species denotes SARS-CoV-2 Tax:2697049
69 506-516 Species denotes SARS-CoV-2 Tax:2697049
70 590-598 Species denotes SARS-CoV Tax:694009
71 838-851 Species denotes coronaviruses Tax:11118
72 1711-1719 Species denotes patients Tax:9606
73 2094-2102 Species denotes patients Tax:9606
74 2185-2193 Species denotes patients Tax:9606
75 2580-2588 Species denotes patients Tax:9606
76 3010-3018 Species denotes patients Tax:9606
77 3341-3349 Species denotes patients Tax:9606
78 3656-3664 Species denotes patients Tax:9606
79 1249-1260 Species denotes respiratory Tax:12814
80 41-50 Disease denotes pneumonia MESH:D011014
81 172-180 Disease denotes COVID-19 MESH:C000657245
82 1188-1197 Disease denotes infection MESH:D007239
83 1658-1667 Disease denotes infection MESH:D007239
84 2085-2093 Disease denotes COVID-19 MESH:C000657245
85 2571-2579 Disease denotes COVID-19 MESH:C000657245
86 2599-2634 Disease denotes acute respiratory distress syndrome MESH:D012128
87 2636-2640 Disease denotes ARDS MESH:D012128
88 2658-2676 Disease denotes hyper inflammation MESH:D007249
89 2769-2784 Disease denotes lymphocytopenia MESH:D008231
90 2960-2982 Disease denotes multiple organ failure MESH:D009102
91 3332-3340 Disease denotes COVID-19 MESH:C000657245
92 3639-3643 Disease denotes ARDS MESH:D012128
93 3647-3655 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-12 Sentence denotes Introduction
T14 13-275 Sentence denotes Following reports of severe pneumonia cases of unknown etiology from Wuhan, China, multiple groups identified the pathogenic agent responsible for the current COVID-19 pandemic as the SARS-CoV-2 virus (Chan et al., 2020; Huang C. et al., 2020; Zhu et al., 2020).
T15 276-476 Sentence denotes The last several months have seen an unprecedented surge in research efforts to understand the underlying molecular mechanisms associated with SARS-CoV-2 infectivity, immunogenicity, and pathogenesis.
T16 477-750 Sentence denotes Since it is now evident that SARS-CoV-2 employs the same set of receptors and host cells, previously utilized by SARS-CoV, various disease models were developed to understand the molecular networks implicated in viral evasion, host immune response, and immuno-pathogenesis.
T17 751-932 Sentence denotes Multiple factors and pathways are already known based on previous knowledge from other coronaviruses, which have shown promising potential as therapeutic targets (Tay et al., 2020).
T18 933-1152 Sentence denotes But a more comprehensive understanding to develop highly effective therapies is yet to emerge, which demands better molecular details at various stages of the virus propagation and disease progression in the host cells.
T19 1153-1379 Sentence denotes In the initial early mild phase of infection (Stage I), the virus remains confined to the upper respiratory tract (nasal cells, some areas of pharynx and larynx) which elicits low levels of the innate immune response (if any).
T20 1380-1537 Sentence denotes This asymptomatic state lasts for a couple of days (generally one or two days) before the virus propagates to the conducting and terminal airways (Stage II).
T21 1538-1668 Sentence denotes During this stage of the disease, an optimal but controlled adaptive and innate immune response will help to combat the infection.
T22 1669-1873 Sentence denotes Successful viral clearance from recovered patients, show the presence of adequate adaptive immune cells along with the immunomodulatory molecules and neutralizing antibodies (Cao, 2020; Tay et al., 2020).
T23 1874-2127 Sentence denotes However, an impaired adaptive immune response at this stage, with concomitant overactivation of the innate immune system (inflammatory macrophages and neutrophils) can lead to severe disease symptoms in ∼20% of COVID-19 patients (Wu and McGoogan, 2020).
T24 2128-2333 Sentence denotes Recent clinical and histopathological data from deceased patients suggest adaptive immune dysfunction and heightened proinflammatory response with inflammatory cell infiltration into the lungs (Stage III).
T25 2334-2549 Sentence denotes Further, the disease severity positively correlated with increased levels of proinflammatory IL-6 and an increase in the neutrophil/lymphocyte ratio (Liu T. et al., 2020; Tan L. et al., 2020b; Tan M. et al., 2020c).
T26 2550-2851 Sentence denotes Between 3 and 17% of COVID-19 patients developed acute respiratory distress syndrome (ARDS), as a result of hyper inflammation (excessive infiltration of activated innate immune cells and cytokine release syndrome) and lymphocytopenia (reduced levels of CD4+, CD8+, and B cells) (Gibson et al., 2020).
T27 2852-3122 Sentence denotes These changes are followed by cell death and tissue destruction, which ultimately leads to airway collapse, multiple organ failure and death in 67–85% of ICU patients, based on the available data so far (Wu and McGoogan, 2020; Xu Z. et al., 2020; Zhang H. et al., 2020).
T28 3123-3286 Sentence denotes Here, we discuss the molecular determinants implicated in the success or failure of recovery through various phases of immune response generated by the host cells.
T29 3287-3564 Sentence denotes We have built an immunological trajectory of COVID-19 patients who have successfully cleared the virus against those who have developed severe symptoms, with emphasis on virus sensing and evasion mechanisms, and the spatiotemporal role of the innate and adaptive immune system.
T30 3565-3665 Sentence denotes Further, we provided cellular and molecular details of cytokine storm and ARDS in COVID-19 patients.