PMC:7736111 / 141563-142287 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
3611	147-150	Gene	denotes	CD8	Gene:925
3612	446-451	Gene	denotes	IL-1β	Gene:3552
3613	453-457	Gene	denotes	IL-6	Gene:3569
3614	463-467	Gene	denotes	IL-8	Gene:3576
3615	524-529	Gene	denotes	CXCL9	Gene:4283
3616	531-537	Gene	denotes	CXCL10	Gene:3627
3617	542-548	Gene	denotes	CXCL11	Gene:6373
3618	643-647	Gene	denotes	IL1B	Gene:3553
3619	649-652	Gene	denotes	IL6	Gene:3569
3620	654-658	Gene	denotes	TNFA	Gene:7124
3621	682-686	Gene	denotes	CCL2	Gene:6347
3622	688-692	Gene	denotes	CCL3	Gene:6348
3623	694-698	Gene	denotes	CCL4	Gene:6351
3624	703-707	Gene	denotes	CCL7	Gene:6354
3693	204-211	Species	denotes	patient	Tax:9606
3694	374-382	Species	denotes	patients	Tax:9606
3695	493-501	Species	denotes	patients	Tax:9606
3696	583-591	Species	denotes	patients	Tax:9606
3770	189-203	Disease	denotes	critically ill	MESH:D016638

Id	Subject	Object	Predicate	Lexical cue
T984	0-724	Sentence	denotes	6 • Single cell RNA-seq analysis was performed followed by cluster analysis to determine the immune cell type.• Proliferative and less expandable CD8+ T lymphocytes were present in severe/critically ill patient BALF samples, whereas moderate cases showed more expandable and less proliferative phenotype.• Increased macrophages and neutrophils were detected in the BALF of patients exhibiting severe/critical disease symptoms.• Higher levels of IL-1β, IL-6, and IL-8 were observed in all the patients.• Increased levels of CXCL9, CXCL10 and CXCL11 were consistently seen in all the patients.• Lung macrophages displayed higher transcripts of IL1B, IL6, TNFA, along with chemokines CCL2, CCL3, CCL4 and CCL7 in severe cases.