PMC:7736111 / 11490-12174 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
267	53-57	Gene	denotes	MAVS	Gene:57506
268	91-94	Gene	denotes	IFN	Gene:3439
269	105-109	Gene	denotes	IRF3	Gene:3661
270	114-118	Gene	denotes	IRF7	Gene:3665
271	224-229	Gene	denotes	NF κB	Gene:4790
272	401-406	Gene	denotes	NF κB	Gene:4790
273	455-461	Gene	denotes	IRF3/7	Gene:3661
274	465-470	Gene	denotes	NF κB	Gene:4790
282	673-677	Species	denotes	mice	Tax:10090

Id	Subject	Object	Predicate	Lexical cue
T61	30-251	Sentence	denotes	Thus, centrally placed MAVS activation induces expression of IFN genes via IRF3 and IRF7 pathways and recruitment of other innate immune cells, majorly by proinflammatory molecules secreted via NF κB signaling (Figure 2).
T62	252-435	Sentence	denotes	Similarly, activation of endogenous TLR pathway induces expression of IFN type I, type III, and more specifically, proinflammatory molecules via the NF κB pathway (Gong et al., 2020).
T63	436-653	Sentence	denotes	Blocking of either IRF3/7 or NF κB pathway has a detrimental effect on host cells that invariably allows propagation of the virus (Lazear et al., 2013; Schmitz et al., 2014; Totura et al., 2015; Chiang and Liu, 2019).